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Enhanced Levels of Insulin-like Growth Factor Messenger RNA in Human Colon Carcinomas and Liposarcomas¹

Department of Human Genetics and Surgical Oncology, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263 [J. V. T., C. P. K., L. H., N. J. P., T. B. S.], and Chiron Corporation, Emeryville, California 94608 [L. B. R., G. I. B.]

The insulin-like growth factors I and II (IGF-I and -II) are proteins which stimulate cell proliferation and are important in normal human growth and development. They are coded for by separate genes and bind to specific cell surface receptors, eliciting a mitogenic response. IGFs are secreted by several cell lines derived from adult tumors. We have examined a number of human adult tumors for IGF messenger RNA (mRNA) expression and found IGF-II mRNA levels were consistently elevated in two types, colon carcinoma and liposarcoma. Adult colonic mucosa contains low levels of IGF-I and -II mRNA while several colon tumors, particularly of rectal and rectosigmoid origin, contained significantly elevated levels of IGF-II message. Over 90% of liposarcomas examined contained greatly elevated levels of IGF-II mRNA while control tissue (adipose) contained very low or undetectable IGF mRNA levels. Many of these tumors also contained elevated IGF-I mRNA levels. Northern analysis of these RNAs revealed differences in the abundance and sizes of IGF transcripts compared to other normal and malignant tissues known to express IGF.

¹ This investigation was supported by American Cancer Society grant CD-62 and NIH grants GM-20454 and CA28853.

² Present address: Department of Obstetrics and Gynecology, Harvard Medical School, Boston, MA 02115. To whom requests for reprints should be addressed.

Received 4/14/86. Revised 8/20/86. Accepted 9/ 4/86.

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