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Immunotherapy of a Murine Lymphoma by Adoptive Transfer of Syngeneic Macrophages Activated with Bisantrene

Laboratory of Tumor Immunology, Chemotherapy Research Department, Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965

Macrophages from mice treated with a novel antineoplastic agent, bisantrene, were shown previously to be highly active in inhibiting the proliferation of tumor cells in culture. These activated cells have now been found to protect mice from dying of progressive tumors when injected into animals. The effect was observed not only in a Winn-type tumor cell neutralization assay but also in a setting of therapeutic intervention. Multiple treatments with bisantrene-activated cells seemed more effective than a single treatment. Macrophages appeared to be the major effectors in this system, since treatment with carrageenan abolished the protective effect. Thus, present findings suggest that in addition to a direct cytotoxic effect of bisantrene, the activation of macrophages may contribute to the overall antitumor activity of the drug.

¹ To whom requests for reprints should be addressed, at Lederle Laboratories, Building 60B, Room 209, Pearl River, NY 10965.

Received 6/11/85. Revised 10/30/85. Accepted 11/ 1/85.