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Surface Membrane O-Alkyl Lipid Concentration and Metastasizing Behavior in Transplantable Rat Mammary Carcinomas¹

Department of Medicine, Division of Endocrinology and Metabolism, The University of Texas Health Science Center, San Antonio, Texas 78284

Whole cell and surface membrane O-alkyl and alk-1-enyl lipid concentrations of 11 transplantable rat mammary carcinomas were measured. A correlation was found between surface membrane O-alkyl lipid levels and metastasizing behavior. No relationship was found between alk-1-enyl lipid concentrations and metastasizing behavior. A possible correlation was found between the product of growth rate and rank order of metastasizing behavior versus surface membrane O-alkyl lipid concentration. Growth rate alone did not correlate with surface membrane O-alkyl lipid concentration.

¹ This investigation was supported by USPHS Grant 2 RO1 CA15047 awarded by the National Cancer Institute, Department of Health and Human Services.

² To whom requests for reprints should be addressed, at Medicine/Endocrinology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284.

Received 8/ 6/85. Revised 10/28/85. Accepted 10/29/85.

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