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Regulation of Myeloma Growth in Mice by Antigen and Regulatory Idiotopes¹

Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029

The effect of antigen, activation of normal A48Id⁺ B-cell clones, and monoclonal antibodies sharing A48-UPC10 regulatory idiotopes on the in vivo growth of spleen adapted ABPC48 myeloma cells has been examined. Immunogenic doses of bacterial levan have no detectable effects, whereas tolerogenic doses substantially delay the growth of the myeloma. The activation of normal A48Id⁺ B cell clones also has no apparent effect on the growth of the ABPC48 myeloma cells. Among a panel of 15 monoclonal antibodies expressing A48-UPC10 regulatory idiotopes and expressing V_H genes derived from the V_H441-4 germ line gene family, 5 were able to provide a long lasting but not definitive idiotype specific protection against the ABPC48 myeloma cells.

¹ Supported by Grant IM-275 from the American Cancer Society.

² To whom requests for reprints should be addressed, at Annenberg 16–60, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029.

Received 6/11/85. Revised 10/25/85. Accepted 12/11/85.