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Increased Persistence of Induced Mutants of Chinese Hamster Cells by 12-O-Tetradecanoylphorbol-13-acetate¹

Institut du Cancer de Montréal, Centre Hospitalier Notre-Dame, Montréal, H2L 4M1, Canada

Hypoxanthine phosphoribosyltransferase deficient mutants of Chinese hamster ovary cells induced by ethyl methanesulfonate usually do not maintain their phenotype during growth in non-selective medium immediately following the induction. This phenomenon, called poor "persistence" of the induced mutation, is in most cases unrelated to growth rate but results from establishment of contact with wild type cells (Bradley, W. E. C. Exp. Cell Res., 129: 251, 1980). We report here that 12-O-tetradecanoylphorbol-13-acetate, a strong tumor promoter, increases the persistence of these mutants.

¹ Supported by grants from the National Cancer Institute of Canada and the Medical Research Council of Canada.

Received 9/ 6/85. Revised 11/22/85. Accepted 12/18/85.