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[Cancer Research 46, 1909-1914, April 1, 1986]
© 1986 American Association for Cancer Research

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Protection from Procarbazine-induced Damage of Spermatogenesis in the Rat by Androgen1

Julian I. Delic2, Cynthia Bush and Michael J. Peckham

Radiotherapy Research Unit, Institute of Cancer Research, Clifton Avenue, Sutton, Surrey, SM2 5PX, United Kingdom

Protection of spermatogenesis from cytotoxic drug-induced damage has been investigated in the rat. Complete germinal aplasia was observed at 8 and 11 weeks after four doses of procarbazine hydrochloride administered weekly (150 mg/kg, first dose; 100 mg/kg, 3 subsequent doses). Pretreatment of rats for 6 weeks plus continued treatment during procarbazine administration with testosterone enanthate, 240 µg/100 g body weight, resulted in a marked protection of spermatogenesis. A mean of 22% of seminiferous tubule cross-sections at both 8 and 11 weeks exhibited spermatogenesis, and developing spermatids were observed in 60% of these repopulating tubules at the later time. These results provide evidence that protection of spermatogenesis during chemotherapy may be achieved by androgen treatment.

1 This investigation was supported by grant 5R01 CA26059, awarded by the National Cancer Institute, Department of Health and Human Services.

2 To whom requests for reprints should be addressed.

Received 6/11/85. Revised 9/24/85. Revised 12/27/85. Accepted 12/30/85.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1986 by the American Association for Cancer Research.