| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Cancer Center/Division of Environmental Sciences, Columbia University, New York, New York 10032 [T. A. D., S. G-C., I. B. W.], and Division of Experimental Oncology A, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy [G. M., G. D. P.]
The expression of endogenous retroviral sequences and of three cellular oncogenes was examined in three hepatocellular adenomas and in four carcinomas induced in male C57BL/6JDp x C3Hf/Dp F1 (hereafter called B6C3F1) mice by a single dose of nitrosodiethylamine, in five carcinomas that arose spontaneously in male C3Hf mice, and in the livers of normal age-matched control mice. In all of these adenomas and carcinomas, there was increased expression of Moloney murine leukemia virus- and intracisternal A particle-related sequences. The retrovirus-like VL30 sequence was expressed at significant levels in the normal liver of these mice and increased expression of this sequence was found in only 4 of the 12 tumors examined. Expression of endogenous mouse mammary tumor virus-related sequences was not detected in the normal livers or in any of the liver tumors. With respect to cellular oncogenes, increased expression of c-myc was seen in all of the B6C3F1 tumors. Two of five normal liver samples and all of the tumors of the C3Hf mice displayed significant expression of c-myc. There was a slight increase in expression of c-Ha-ras in some of the tumors. Increased expression of c-fos was found in only 1 of the 12 tumors. Taken together, these studies indicate that both carcinogen-induced and spontaneous liver tumor formation in mice is associated with abnormalities in the expression of endogenous retrovirus-related DNA sequences and also specific cellular oncogenes.
1 This investigation was partially supported by an Associazione Italiana per la Ricerca sul Cancro (A.I.R.C.) fellowship to T. A. Dragani, by a grant from the Finalized Project "Oncology," Consiglio Nazionale delle Ricerche (C.N.R.), Rome, Italy, and by a National Cancer Institute Grant 021111 and funding from the National Foundation for Cancer Research to I. B. Weinstein.
2 To whom reprints for reports should be addressed.
Received 9/30/85. Revised 12/23/85. Accepted 12/30/85.
This article has been cited by other articles:
![]() |
I. A. Maksakova and D. L. Mager Transcriptional Regulation of Early Transposon Elements, an Active Family of Mouse Long Terminal Repeat Retrotransposons J. Virol., November 15, 2005; 79(22): 13865 - 13874. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Fujiwara, M. Ochiai, T. Ohta, M. Ohki, H. Aburatani, M. Nagao, T. Sugimura, and H. Nakagama Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Carcinogenesis, August 1, 2004; 25(8): 1495 - 1505. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Ogawa, M. Osanai, M. Obata, K. Ishizaki, and K. Kamiya Gain of chromosomes 15 and 19 is frequent in both mouse hepatocellular carcinoma cell lines and primary tumors, but loss of chromosomes 4 and 12 is detected only in the cell lines Carcinogenesis, November 1, 1999; 20(11): 2083 - 2088. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. R. De Miglio, F. Canzian, R. M. Pascale, M. M. Simile, M. R. Muroni, D. Calvisi, G. Romeo, and F. Feo Identification of Genetic Loci Controlling Hepatocarcinogenesis on Rat Chromosomes 7 and 10 Cancer Res., September 1, 1999; 59(18): 4651 - 4657. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. D. Porta, T. A. Dragani, and G. Manenti Two-Stage Liver Carcinogenesis in the Mouse Toxicol Pathol, February 1, 1987; 15(2): 229 - 233. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |