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Departments of Cell Biology [G. D. S., R. J. W., R. E. S., H. L. M.], Dermatology [M. R. P.], and Pathology [R. E. S., H. L. M.], Mayo Clinic/Foundation, Rochester, Minnesota 55905
Type ß transforming growth factor-growth inhibitor (TGFß/GI) causes normal human prokeratinocytes to arrest growth predominantly in the G1 phase of the cell cycle within 48 h after log phase cultures are exposed to the factor in serum-free medium. The growth arrest induced by TGFß/GI is reversible because the cells from treated cultures can be replated into fresh medium and grown into large colonies. Normal prokeratinocytes are demonstrated to secrete TGFß/GI-like molecules into the culture medium and to have specific cell surface receptors for this molecule. In contrast, a human squamous cell carcinoma, SCC-25, does not arrest growth when exposed to TGFß/GI. These cells, unlike the normal prokeratinocytes, do not exhibit detectable cell surface receptors for the factor.
1 This work was supported by NIH CA16816 and NIH CA27217 to H. L. M., NIH CA39911 to G. D. S., NIH CA28240 to R. E. S., and the Mayo Foundation.
2 To whom requests for reprints should be addressed, at Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232.
Received 6/18/85. Revised 12/ 3/85. Accepted 1/ 2/86.
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