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Inhibitory Effect of Dietary Selenium on Carcinogenesis in Rat Glandular Stomach Induced by N-Methyl-N'-nitro-N-nitrosoguanidine¹

Department of Surgery, Kansai Medical University, 1 Fumizono, Moriguchi, Osaka 570, Japan

The influence of dietary selenium on the incidence of stomach carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine was studied in 108 rats that survived for over 10 wk. The incidence of glandular stomach cancer in the high-selenium (4.0 ppm) diet group (20 carcinomas in 54 rats) was lower than in the low-selenium (0.1 ppm) diet group (33 carcinomas in 54 rats). The selenium level and glutathione peroxidase activity in the blood, liver, and stomach mucosa were significantly higher in the high-selenium diet group than in the low-selenium diet group. Glutathione peroxidase activity as well as the concentration of selenium in the glandular stomach was increased significantly in the high-selenium diet group.

¹ Supported by a Grant-in-Aid for the Encouragement of Young Scientists of the Ministry of Education, Science, and Culture of Japan (59770919).

² To whom requests for reprints should be addressed.

Received 5/17/85. Revised 12/27/85. Accepted 1/16/86.

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