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Effects of Chronic Daily Exposure to Tobacco Smoke on the High Leukemic AKR Strain of Mice¹

Department of Microbiology, University of Western Australia, Nedlands, Western Australia 6009

Daily exposure of the high leukemic AKR strain of mice to low levels of fresh tobacco smoke (TS) produces significantly different mortality profiles associated with both the sex of the animals and the age at which TS exposure commences. Females tend to be susceptible and die sooner than males, where a significant proportion of animals survives longer than age-matched controls. This prolongation of life appears to be due to a failure of the leukemic state to be mobilized in the TS-exposed males. Exposure of both the females and the males to the TS does not induce significant detectable immunological reactivity against the leukemic cells for several parameters tested, possibly due to a significant enhancement of suppressor activity in the serum of the chronically exposed animals over and above that which also occurs in age-matched control animals.

¹ This work was carried out under a research grant from the Australian Tobacco Research Foundation.

² To whom requests for reprints should be addressed, at Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009.

Received 10/15/85. Revised 3/10/86. Accepted 3/20/86.