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Divisions of Nutrition and Endocrinology [B. S. R.] and Experimental Pathology and Toxicology [H. M.], Naylor Dana Institute for Disease Prevention, Valhalla, New York 10595
The effect of dietary intake of different levels of Menhaden fish oil on azoxymethane-induced carcinogenesis was examined in male F344 rats fed the semipurified diets. Starting at 5 weeks of age, groups of animals were fed the 5% corn oil (low corn oil) diet. At 7 weeks of age, all animals except the vehicle-treated controls were given s.c. injections of azoxymethane (15 mg/kg body weight/week for 2 weeks). After 4 days, groups of animals were fed the diets containing 4% Menhaden oil + 1% corn oil (low fish oil), 22.5% Menhaden oil + 1% corn oil (high fish oil), 5% corn oil, and 23.5% corn oil (high corn oil). Thirty-four weeks after azoxymethane injections, all animals were necropsied. High fish oil diet had no tumor promoting effect in the large intestine when compared to the high corn oil diet. There was no difference in large intestinal tumor incidence among the other dietary groups. The results of this study indicate that fish oils rich in highly polyunsaturated n-3 fatty acids do not enhance large bowel carcinogenesis and that the fatty acid composition of the dietary fat is one of the determining factors in large bowel carcinogenesis.
1 This investigation was supported by Public Health Service grants CA-17613 and CA-37663 from the National Cancer Institute. Animals were maintained under the guidelines set forth in the "Guide for the Care and Use of Laboratory Animal Resources" by the National Research Council.
2 To whom requests for reprints should be addressed.
Received 1/14/86. Revised 3/21/86. Accepted 3/25/86.
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