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Differences in Phosphate Metabolite Levels in Drug-sensitive and -resistant Human Breast Cancer Cell Lines Determined by ³¹P Magnetic Resonance Spectroscopy¹

Clinical Pharmacology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892

³¹P magnetic resonance spectra of perfused human breast cancer cells with the phenotype of pleiotropic drug resistance exhibit striking differences in the levels of phosphate metabolites from the wild-type, drug-sensitive parent cell line. Resistant cells demonstrated elevated levels of phosphocreatine and depressed levels of phosphomonoesters, phosphodiesters, and diphosphodiesters. These differences may reflect significant alterations in the control of bioenergetic metabolism between drug-resistant and -sensitive cells.

¹ Part of this work was presented at the third meeting of the Society of Magnetic Resonance in Medicine, London, August 1985.

² Present address: Montreal General Hospital Research Institute, Room 960, 1650 Cedar Avenue, Montreal, Canada H3G-1A4.

Received 12/10/85. Revised 4/14/86. Accepted 4/16/86.

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