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[Cancer Research 47, 2558-2562, May 15, 1987]
© 1987 American Association for Cancer Research
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Modification of Cell Surface Glycoproteins, Macrophage Cytostasis, and Blood-borne Metastatic Properties of the Murine RAW117 Large Cell Lymphoma by Virus Superinfection1

Mitsuzi Yoshida2, Gary E. Gallick3, Tatsuro Irimura4 and Garth L. Nicolson5

Department of Tumor Biology, The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77030

Highly metastatic sublines of the murine RAW117-P large cell lymphoma parental line have been selected sequentially in vivo for enhanced blood-borne organ colonization. We found that the subline RAW117-H10, selected 10 times for liver colonization, formed more than 200 times as many liver tumor nodules than the RAW117-P line and showed loss of cell surface RNA tumor virus Mr 70,000 envelope glycoprotein and sensitivity to activated macrophage-mediated cytostasis. Superinfection of RAW117-H10 cells with endogenous RNA tumor virus isolated from RAW117-P cells caused increases in Mr 70,000 envelope glycoprotein expression and sensitivity to activated macrophage-mediated cytostasis concomitant with loss of liver metastatic properties. The results suggest that RAW117 cell surface Mr 70,000 envelope glycoprotein is involved in host macrophage-mediated surveillance mechanisms and metastatic properties.

1 Supported by National Cancer Institute Grant R01-CA29571 to G. L. Nicolson.

2 Present address: Pharmacology Division, National Cancer Center Research Institutes, Tsukiji 5-chome, Chuo-ku, Tokyo 104, Japan.

3 Supported by National Cancer Institute Grant R23-CA39803.

4 Supported by National Cancer Institute Grant R01-CA39319.

5 To whom requests for reprints should be addressed.

Received 8/25/86. Revised 2/16/87. Accepted 2/19/87.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1987 by the American Association for Cancer Research.