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Influences of Strain and Diet on the Promoting Effects of Sodium L-Ascorbate in Two-Stage Urinary Bladder Carcinogenesis in Rats

Aburahi Laboratories, Shionogi Research Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34 [S. M., Y. T., M. T., S. M.] and First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467 [S. M., Y. K., S. F.], Japan

The influences of strain and diet on the promoting effects of sodium L-ascorbate (SA) on two-stage urinary bladder carcinogenesis was investigated in male F344 and Lewis rats. Two kinds of commercial basal diets, Oriental MF and Clea CA-1, were used. Rats were given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine in their drinking water for 4 weeks and then basal diet with 5% SA or without SA for 32 weeks. Treatment with SA increased the induction of neoplastic lesions of the urinary bladder in rats initiated by 0.05% N-butyl-N-(4-hydroxybutyl)mitrosamine. The promoting effect of SA for urinary bladder carcinogenesis was: F344 strain-Oriental MF diet > Lewis strain-Clea CA-1 diet > F344 strain-Clea CA-1 diet = Lewis strain-Oriental MF diet. In both strains or with both diets, SA-treatment increased the urinary pH and the concentrations of sodium ion and total ascorbic acid. These results demonstrate that strain and diet strongly influence susceptibility to the SA-promoting effects in rat urinary bladder carcinogenesis.

¹ To whom requests for reprints should be addressed, at First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan.

Received 11/13/86. Revised 3/25/87. Accepted 3/31/87.

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