| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Pathology [T. Ka., K. N., T. Ki.] and Department of Viral Oncology [Y. H.], Cancer Institute, Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan
A hepatocellular carcinoma cell line, LMH, has been established from a hepatocellular carcinoma induced in a male leghorn chicken by diethylnitrosamine. The cell line is characterized by well-differentiated morphological and biochemical features including the expression of glucose-6-phosphatase and canalicular ATPase activities and triploid karyotype with six marker chromosomes.
The cells have been continuously propagated in culture for 5 yr and are now at about the 120th passage. Morphological change occurred in culture associated with gradual increase in growth rate at about the 40th passage. However, the biochemical and chromosomal features remained constant.
This is the first established domestic fowl epithelial cell line and will allow comparative investigation of a number of parameters relevant to chicken hepatocarcinogenesis.
1 Supported by a grant-in-aid for cancer research from the Ministry of Education, Science, and Culture of Japan.
2 To whom requests for reprints should be addressed.
Received 1/27/87. Revised 5/ 6/87. Accepted 5/13/87.
This article has been cited by other articles:
|
|
 |
|
  B. Quinones, W. G. Miller, A. H. Bates, and R. E. Mandrell Autoinducer-2 Production in Campylobacter jejuni Contributes to Chicken Colonization Appl. Envir. Microbiol., January 1, 2009; 75(1): 281 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Maenz, C. Loscher, A. Iwanski, and M. Bruns Inhibition of duck hepatitis B virus infection of liver cells by combined treatment with viral e antigen and carbohydrates J. Gen. Virol., December 1, 2008; 89(12): 3016 - 3026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Banadyga, J. Gerig, T. Stewart, and M. Barry Fowlpox Virus Encodes a Bcl-2 Homologue That Protects Cells from Apoptotic Death through Interaction with the Proapoptotic Protein Bak J. Virol., October 15, 2007; 81(20): 11032 - 11045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Maenz, S.-F. Chang, A. Iwanski, and M. Bruns Entry of Duck Hepatitis B Virus into Primary Duck Liver and Kidney Cells after Discovery of a Fusogenic Region within the Large Surface Protein J. Virol., May 15, 2007; 81(10): 5014 - 5023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Helferich, J. Veits, T. C. Mettenleiter, and W. Fuchs Identification of transcripts and protein products of the UL31, UL37, UL46, UL47, UL48, UL49 and US4 gene homologues of avian infectious laryngotracheitis virus J. Gen. Virol., March 1, 2007; 88(3): 719 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Helferich, J. Veits, J. P. Teifke, T. C. Mettenleiter, and W. Fuchs The UL47 gene of avian infectious laryngotracheitis virus is not essential for in vitro replication but is relevant for virulence in chickens J. Gen. Virol., March 1, 2007; 88(3): 732 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Basagoudanavar, D. H. Perlman, and J. Hu Regulation of Hepadnavirus Reverse Transcription by Dynamic Nucleocapsid Phosphorylation J. Virol., February 15, 2007; 81(4): 1641 - 1649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Devlin, G. F. Browning, C. A. Hartley, N. C. Kirkpatrick, A. Mahmoudian, A. H. Noormohammadi, and J. R. Gilkerson Glycoprotein G is a virulence factor in infectious laryngotracheitis virus. J. Gen. Virol., October 1, 2006; 87(Pt 10): 2839 - 2847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Guo, W. S. Mason, C. E. Aldrich, J. R. Saputelli, D. S. Miller, A. R. Jilbert, and J. E. Newbold Identification and Characterization of Avihepadnaviruses Isolated from Exotic Anseriformes Maintained in Captivity J. Virol., March 1, 2005; 79(5): 2729 - 2742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Fuchs, D. Wiesner, J. Veits, J. P. Teifke, and T. C. Mettenleiter In Vitro and In Vivo Relevance of Infectious Laryngotracheitis Virus gJ Proteins That Are Expressed from Spliced and Nonspliced mRNAs J. Virol., January 15, 2005; 79(2): 705 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Veits, D. Luschow, K. Kindermann, O. Werner, J. P. Teifke, T. C. Mettenleiter, and W. Fuchs Deletion of the non-essential UL0 gene of infectious laryngotracheitis (ILT) virus leads to attenuation in chickens, and UL0 mutants expressing influenza virus haemagglutinin (H7) protect against ILT and fowl plague J. Gen. Virol., December 1, 2003; 84(12): 3343 - 3352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Habig and D. D. Loeb The Conformation of the 3' End of the Minus-Strand DNA Makes Multiple Contributions to Template Switches during Plus-Strand DNA Synthesis of Duck Hepatitis B Virus J. Virol., December 1, 2003; 77(23): 12401 - 12411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Habig and D. D. Loeb Template Switches during Plus-Strand DNA Synthesis of Duck Hepatitis B Virus Are Influenced by the Base Composition of the Minus-Strand Terminal Redundancy J. Virol., December 1, 2003; 77(23): 12412 - 12420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Veits, T. C. Mettenleiter, and W. Fuchs Five unique open reading frames of infectious laryngotracheitis virus are expressed during infection but are dispensable for virus replication in cell culture J. Gen. Virol., June 1, 2003; 84(6): 1415 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Fragnet, M. A. Blasco, W. Klapper, and D. Rasschaert The RNA Subunit of Telomerase Is Encoded by Marek's Disease Virus J. Virol., May 15, 2003; 77(10): 5985 - 5996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-T. Guo, M. Pryce, X. Wang, M. I. Barrasa, J. Hu, and C. Seeger Conditional Replication of Duck Hepatitis B Virus in Hepatoma Cells J. Virol., February 1, 2003; 77(3): 1885 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Perlman and J. Hu Duck Hepatitis B Virus Virion Secretion Requires a Double-Stranded DNA Genome J. Virol., February 1, 2003; 77(3): 2287 - 2294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lobmayr, T. Sauer, I. Killisch, M. Schranzhofer, R. B. Wilson, P. Ponka, H. Beug, and E. W. Mullner Transferrin receptor hyperexpression in primary erythroblasts is lost on transformation by avian erythroblastosis virus Blood, June 17, 2002; 100(1): 289 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Da Costa, C. Chevalier, C. Henry, J.-C. Huet, S. Petit, J. Lepault, H. Boot, and B. Delmas The Capsid of Infectious Bursal Disease Virus Contains Several Small Peptides Arising from the Maturation Process of pVP2 J. Virol., March 1, 2002; 76(5): 2393 - 2402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Habig and D. D. Loeb Small DNA Hairpin Negatively Regulates In Situ Priming during Duck Hepatitis B Virus Reverse Transcription J. Virol., February 1, 2002; 76(3): 980 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Pult, N. Abbott, Y.-Y. Zhang, and J. Summers Frequency of Spontaneous Mutations in an Avian Hepadnavirus Infection J. Virol., October 15, 2001; 75(20): 9623 - 9632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Handschin, M. Podvinec, J. Stockli, K. Hoffmann, and U. A. Meyer Conservation of Signaling Pathways of Xenobiotic-Sensing Orphan Nuclear Receptors, Chicken Xenobiotic Receptor, Constitutive Androstane Receptor, and Pregnane X Receptor, from Birds to Humans Mol. Endocrinol., September 1, 2001; 15(9): 1571 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Tan, A.-I. Michou, J. M. Bergelson, and M. Cotten Defining CAR as a cellular receptor for the avian adenovirus CELO using a genetic analysis of the two viral fibre proteins J. Gen. Virol., June 1, 2001; 82(6): 1465 - 1472. [Abstract] [Full Text]
|
|
|
|
|
|
A. François, N. Eterradossi, B. Delmas, V. Payet, and P. Langlois Construction of Avian Adenovirus CELO Recombinants in Cosmids J. Virol., June 1, 2001; 75(11): 5288 - 5301. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. E. Heid, M. K. Walker, and H. I. Swanson Correlation of Cardiotoxicity Mediated by Halogenated Aromatic Hydrocarbons to Aryl Hydrocarbon Receptor Activation Toxicol. Sci., May 1, 2001; 61(1): 187 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Granzow, B. G. Klupp, W. Fuchs, J. Veits, N. Osterrieder, and T. C. Mettenleiter Egress of Alphaherpesviruses: Comparative Ultrastructural Study J. Virol., April 15, 2001; 75(8): 3675 - 3684. [Abstract] [Full Text]
|
|
|
|
|
|
M. I. Barrasa, J.-T. Guo, J. Saputelli, W. S. Mason, and C. Seeger Does a cdc2 Kinase-Like Recognition Motif on the Core Protein of Hepadnaviruses Regulate Assembly and Disintegration of Capsids? J. Virol., February 15, 2001; 75(4): 2024 - 2028. [Abstract] [Full Text]
|
|
|
|
|
|
H. Mabit and H. Schaller Intracellular Hepadnavirus Nucleocapsids Are Selected for Secretion by Envelope Protein-Independent Membrane Binding J. Virol., December 15, 2000; 74(24): 11472 - 11478. [Abstract] [Full Text]
|
|
|
|
|
|
J. Chang, G. Moraleda, and J. Taylor Limitations to Replication of Hepatitis Delta Virus in Avian Cells J. Virol., October 1, 2000; 74(19): 8861 - 8866. [Abstract] [Full Text]
|
|
|
|
|
|
F. Dorange, S. El Mehdaoui, C. Pichon, P. Coursaget, and J.-F. Vautherot Marek's disease virus (MDV) homologues of herpes simplex virus type 1 UL49 (VP22) and UL48 (VP16) genes: high-level expression and characterization of MDV-1 VP22 and VP16 J. Gen. Virol., September 1, 2000; 81(9): 2219 - 2230. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-Y. Zhang and J. Summers Low Dynamic State of Viral Competition in a Chronic Avian Hepadnavirus Infection J. Virol., June 1, 2000; 74(11): 5257 - 5265. [Abstract] [Full Text]
|
|
|
|
|
|
W. Fuchs, K. Ziemann, J. P. Teifke, O. Werner, and T. C. Mettenleiter The non-essential UL50 gene of avian infectious laryngotracheitis virus encodes a functional dUTPase which is not a virulence factor J. Gen. Virol., March 1, 2000; 81(3): 627 - 638. [Abstract] [Full Text]
|
|
|
|
|
|
W. Fuchs and T. C. Mettenleiter DNA sequence of the UL6 to UL20 genes of infectious laryngotracheitis virus and characterization of the UL10 gene product as a nonglycosylated and nonessential virion protein J. Gen. Virol., August 1, 1999; 80(8): 2173 - 2182. [Abstract] [Full Text]
|
|
|
|
|
|
U. Schultz, J. Summers, P. Staeheli, and F. V. Chisari Elimination of Duck Hepatitis B Virus RNA-Containing Capsids in Duck Interferon-Alpha-Treated Hepatocytes J. Virol., July 1, 1999; 73(7): 5459 - 5465. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-Y. Zhang and J. Summers Enrichment of a Precore-Minus Mutant of Duck Hepatitis B Virus in Experimental Mixed Infections J. Virol., May 1, 1999; 73(5): 3616 - 3622. [Abstract] [Full Text]
|
|
|
|
|
|
A.-I. Michou, H. Lehrmann, M. Saltik, and M. Cotten Mutational Analysis of the Avian Adenovirus CELO, Which Provides a Basis for Gene Delivery Vectors J. Virol., February 1, 1999; 73(2): 1399 - 1410. [Abstract] [Full Text]
|
|
|
|
|
|
S. S. Gong, A. D. Jensen, C. J. Chang, and C. E. Rogler Double-Stranded Linear Duck Hepatitis B Virus (DHBV) Stably Integrates at a Higher Frequency than Wild-Type DHBV in LMH Chicken Hepatoma Cells J. Virol., February 1, 1999; 73(2): 1492 - 1502. [Abstract] [Full Text]
|
|
|
|
|
|
W. Yang and J. Summers Infection of Ducklings with Virus Particles Containing Linear Double-Stranded Duck Hepatitis B Virus DNA: Illegitimate Replication and Reversion J. Virol., November 1, 1998; 72(11): 8710 - 8717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kock, S. Wieland, H. E. Blum, and F. von Weizsacker Duck Hepatitis B Virus Nucleocapsids Formed by N-Terminally Extended or C-Terminally Truncated Core Proteins Disintegrate during Viral DNA Maturation J. Virol., November 1, 1998; 72(11): 9116 - 9120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Elbirt, A. J. Whitmarsh, R. J. Davis, and H. L. Bonkovsky Mechanism of Sodium Arsenite-mediated Induction of Heme Oxygenase-1 in Hepatoma Cells. ROLE OF MITOGEN-ACTIVATED PROTEIN KINASES J. Biol. Chem., April 10, 1998; 273(15): 8922 - 8931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bruns, S. Miska, S. Chassot, and H. Will Enhancement of Hepatitis B Virus Infection by Noninfectious Subviral Particles J. Virol., February 1, 1998; 72(2): 1462 - 1468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Z. He and J. B. E. Burch The Chicken GATA-6 Locus Contains Multiple Control Regions That Confer Distinct Patterns of Heart Region-specific Expression in Transgenic Mouse Embryos J. Biol. Chem., November 7, 1997; 272(45): 28550 - 28556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Savon, P. Hakimi, D. R. Crawford, D. J. Klemm, A. L. Gurney, and R. W. Hanson The Promoter Regulatory Regions of the Genes for the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) from the Chicken and the Rat Have Different Species-Specific Roles in Gluconeogenesis J. Nutr., February 1, 1997; 127(2): 276 - 285. [Abstract] [Full Text]
|
|
|
|
|
|
M. Schwemmle, B. Kaspers, A. Irion, P. Staeheli, and U. Schultz Chicken Guanylate-binding Protein J. Biol. Chem., April 26, 1996; 271(17): 10304 - 10308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B Pain, M. Clark, M Shen, H Nakazawa, M Sakurai, J Samarut, and R. Etches Long-term in vitro culture and characterisation of avian embryonic stem cells with multiple morphogenetic potentialities Development, January 8, 1996; 122(8): 2339 - 2348. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
