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The Oncology Center, The Johns Hopkins University School of Medicine [B. V., E. R. F., S. R. H., A. C. P.], Department of Pathology, The Johns Hopkins Hospital [S. R. H.], Baltimore, Maryland; Department of Medical Genetics, University of Toronto, Toronto, OHI, Canada [H. F. W.]; Division of Hematology-Oncology, Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts [A. M. M., S. H. O.]; and Department of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, California [A. D. R.]
It has been demonstrated that restriction fragment length polymorphisms of X-chromosome genes can be used in conjunction with methylation patterns to determine the clonal composition of human tumors. In this report, we show that several X-chromosome probes can be used for such analyses. In particular, probes derived from the hypoxanthine phosphoribosyltransferase gene and the phosphoglycerate kinase gene could be used for clonal analysis in over 50% of American females. The X-inactivation patterns observed with these probes were found to accurately reflect clonality in more than 95% of 92 tumors tested.
1 This work was supported by the Clayton Foundation, the Smith Foundation, Grant MA-7805 from the Medical Research Council of Canada (H. F. W.), and Grants GM31263 (A. D. R.), HD-18128 (S. H. O.), GM-07309 (E. R. F.), GM-07184 (E. R. F.), and CA-35494 (B. V.), awarded by the NIH, Department of Health and Human Services.
2 To whom requests for reprints should be addressed, at Oncology, 1-127, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21205.
3 An investigator of the Howard Hughes Medical Institute.
Received 3/11/87. Revised 6/15/87. Accepted 6/23/87.
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