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Promotion by L-Ascorbic Acid of Urinary Bladder Carcinogenesis in Rats under Conditions of Increased Urinary K Ion Concentration and pH¹

First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan

Dietary administration of 5% L-ascorbic acid plus 3% K₂CO₃ to male F344 rats clearly enhanced the development of preneoplastic and neoplastic lesions of the urinary bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Promotion of carcinogenesis by L-ascorbic acid and K₂CO₃ was associated with changes in urinary parameters: elevation of pH, increased K⁺ concentration, and increase in total ascorbic acid.

¹ This work was supported by Grants-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, and the Ministry of Health and Welfare of Japan, and by a Grant-in-Aid from the Ministry of Health and Welfare for a Comprehensive 10 Year Strategy for Cancer Control, Japan.

² To whom requests for reprints should be addressed, at the First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuhocho, Mizuho-ku, Nagoya 467, Japan.

Received 3/25/87. Revised 6/18/87. Accepted 6/23/87.