This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Song, C. W. Articles by Levitt, S. H. Search for Related Content PubMed PubMed Citation Articles by Song, C. W. Articles by Levitt, S. H.

Increase in pO₂ and Radiosensitivity of Tumors by Fluosol-DA (20%) and Carbogen¹

Department of Therapeutic Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455

The potential usefulness of i.v. injection of perfluorochemicals and breathing carbogen (95% O₂ and 5% CO₂) to improve the radiationinduced control of tumors was investigated. When C3H mice, bearing RIF-1 tumors in the legs, were given i.v. injections of Fluosol-DA (20%) at 12 ml/kg, and allowed to breathe carbogen for 1 h before and during a single dose of X-irradiation, the curability of tumors increased by a dose modification factor of 1.47 ± 0.03 (SE). Such a treatment also increased the radiation-induced skin damage by a factor of 1.15 ± 0.12, resulting in a therapeutic gain of 1.28 ± 0.04. Measurement of intratumor pO₂ by oxygen microelectrodes demonstrated small increases in pO₂ when the animals breathed carbogen, and marked increases in pO₂ when Fluosol-DA (20%) was injected into the animals and the animals breathed carbogen. It was concluded that i.v. injection of Fluosol-DA (20%) followed by carbogen breathing significantly improved the oxygen supply to hypoxic cells in the RIF-1 tumors and thus increased the control of tumors by radiation.

¹ This work was supported by National Cancer Institute Grant CA13353 and by a grant from Alpha Therapeutic Corp.

² To whom requests for reprints should be addressed, at University of Minnesota Medical School, Department of Therapeutic Radiology, 420 Delaware St. S.E., Box 494 Mayo Memorial Building, Minneapolis, MN 55455.

³ Present address: Kansai Medical University, The Department of Radiology, 1, Fumizono-cho, Moriguchi-City, Osaka, 570, Japan.

Received 4/ 7/86. Revised 9/19/86. Accepted 10/ 1/86.