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MRC Center for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg 7505, South Africa
The overall 5-methylcytosine content of DNA from normal, benign hyperplastic, and neoplastic human prostate tissue was analyzed. DNA methylation levels were significantly lower in prostates with benign prostatic hyperplasia and metastatic tumors. In contrast, nonmetastatic prostate tumor DNA had a 5-methylcytosine content essentially the same as in normal tissue. The results suggest a correlation between hypomethylation and metastatic capacity.
1 Supported by the National Cancer Association of South Africa.
2 To whom requests for reprints should be addressed, at MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, P. O. Box 63, Tygerberg 7505, South Africa.
Received 4/10/87. Revised 7/ 9/87. Accepted 7/13/87.
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