Cancer Research Annual Meeting 2010 Telomeres
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 47, 5476-5482, October 15, 1987]
© 1987 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Burchell, J.
Right arrow Articles by Lamport, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Burchell, J.
Right arrow Articles by Lamport, D.

Development and Characterization of Breast Cancer Reactive Monoclonal Antibodies Directed to the Core Protein of the Human Milk Mucin

Joy Burchell, Sandra Gendler, Joyce Taylor-Papadimitriou, Anne Girling, Angela Lewis, Rosemary Millis and Derek Lamport

Imperial Cancer Research Fund, P. O. Box 123, Lincoln's Inn Fields, London WC2A 3PX, [J. B., S. G., J. T-P., A. L.]; Imperial Cancer Research Fund Breast Cancer Unit, Guy's Hospital, London SE1 9RT [A. G., R. M.] United Kingdom; and Michigan State University, East Lansing, Michigan [D. L.]

A mucin molecule, which has a molecular weight of greater than 400,000 and which carries tumor associated epitopes recognized by monoclonal antibodies HMFG-1 and HMFG-2, has been purified from human skimmed milk by affinity chromatography followed by passage through a size exclusion column. While treatment of the mucin with hydrogen fluoride for 1 h at 4°C removed the peripheral oligosaccharides, treatment with HF for 3 h at room temperature removed all of its lectin binding ability and revealed a dominant polypeptide of about 68,000. This appears to be the size of the mucin core protein. Monoclonal antibodies have been developed that react with the stripped and partially stripped molecule but not with the intact mucin. From the initial screening on histological sections one of these antibodies, SM-3, reacts with 91% of breast carcinomas but shows little or no reactivity on benign mammary tumors, normal resting, pregnant, or lactating breast. It appears that this monoclonal antibody is reacting with an epitope that is usually masked by oligosaccharide moieties in normal cells but which is exposed, perhaps due to aberrant glycosylation, in malignant cells.

Received 1/14/87. Revised 5/22/87. Accepted 6/24/87.




This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
N. Dharmaraj, S. J. Gendler, and D. D. Carson
Expression of Human MUC1 During Early Pregnancy in the Human MUC1 Transgenic Mouse Model
Biol Reprod, December 1, 2009; 81(6): 1182 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
T. Yue, I. J. Goldstein, M. A. Hollingsworth, K. Kaul, R. E. Brand, and B. B. Haab
The Prevalence and Nature of Glycan Alterations on Specific Proteins in Pancreatic Cancer Patients Revealed Using Antibody-Lectin Sandwich Arrays
Mol. Cell. Proteomics, July 1, 2009; 8(7): 1697 - 1707.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Maher and S. Wilkie
CAR Mechanics: Driving T Cells into the MUC of Cancer
Cancer Res., June 1, 2009; 69(11): 4559 - 4562.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
L. H. SCHMIDT, S. BIESTERFELD, A. KUMMEL, A. FALDUM, M. SEBASTIAN, C. TAUBE, R. BUHL, and R. WIEWRODT
Tissue Microarrays are Reliable Tools for the Clinicopathological Characterization of Lung Cancer Tissue
Anticancer Res, January 1, 2009; 29(1): 201 - 209.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Wilkie, G. Picco, J. Foster, D. M. Davies, S. Julien, L. Cooper, S. Arif, S. J. Mather, J. Taylor-Papadimitriou, J. M. Burchell, et al.
Retargeting of Human T Cells to Tumor-Associated MUC1: The Evolution of a Chimeric Antigen Receptor
J. Immunol., April 1, 2008; 180(7): 4901 - 4909.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
P. Wang, J. A Julian, and D. D Carson
The MUC1 HMFG1 Glycoform Is a Precursor to the 214D4 Glycoform in the Human Uterine Epithelial Cell Line, HES
Biol Reprod, February 1, 2008; 78(2): 290 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Cloosen, J. Arnold, M. Thio, G. M.J. Bos, B. Kyewski, and W. T.V. Germeraad
Expression of Tumor-Associated Differentiation Antigens, MUC1 Glycoforms and CEA, in Human Thymic Epithelial Cells: Implications for Self-Tolerance and Tumor Therapy
Cancer Res., April 15, 2007; 67(8): 3919 - 3926.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
R. Singh, U. Samant, S. Hyland, P. R. Chaudhari, W. S. Wels, and D. Bandyopadhyay
Target-specific cytotoxic activity of recombinant immunotoxin scFv(MUC1)-ETA on breast carcinoma cells and primary breast tumors
Mol. Cancer Ther., February 1, 2007; 6(2): 562 - 569.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
M. A. Tarp, A. L. Sorensen, U. Mandel, H. Paulsen, J. Burchell, J. Taylor-Papadimitriou, and H. Clausen
Identification of a novel cancer-specific immunodominant glycopeptide epitope in the MUC1 tandem repeat
Glycobiology, February 1, 2007; 17(2): 197 - 209.
[Abstract] [Full Text] [PDF]

Home page
 Protein Eng Des SelHome page
C.-Y. Xiong, A. Natarajan, X.-B. Shi, G. L. Denardo, and S. J. Denardo
Development of tumor targeting anti-MUC-1 multimer: effects of di-scFv unpaired cysteine location on PEGylation and tumor binding
Protein Eng. Des. Sel., August 1, 2006; 19(8): 359 - 367.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
A. L. Sorensen, C. A. Reis, M. A. Tarp, U. Mandel, K. Ramachandran, V. Sankaranarayanan, T. Schwientek, R. Graham, J. Taylor-Papadimitriou, M. A. Hollingsworth, et al.
Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance
Glycobiology, February 1, 2006; 16(2): 96 - 107.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
F. Santos-Silva, A. Fonseca, T. Caffrey, F. Carvalho, P. Mesquita, C. Reis, R. Almeida, L. David, and M. A. Hollingsworth
Thomsen-Friedenreich antigen expression in gastric carcinomas is associated with MUC1 mucin VNTR polymorphism
Glycobiology, May 1, 2005; 15(5): 511 - 517.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
B. Agrawal and B. M. Longenecker
MUC1 mucin-mediated regulation of human T cells
Int. Immunol., April 1, 2005; 17(4): 391 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Y. Tsang, C. Palena, J. Yokokawa, P. M. Arlen, J. L. Gulley, G. P. Mazzara, L. Gritz, A. Gomez Yafal, S. Ogueta, P. Greenhalgh, et al.
Analyses of Recombinant Vaccinia and Fowlpox Vaccine Vectors Expressing Transgenes for Two Human Tumor Antigens and Three Human Costimulatory Molecules
Clin. Cancer Res., February 15, 2005; 11(4): 1597 - 1607.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
U. Karsten, N. Serttas, H. Paulsen, A. Danielczyk, and S. Goletz
Binding patterns of DTR-specific antibodies reveal a glycosylation-conditioned tumor-specific epitope of the epithelial mucin (MUC1)
Glycobiology, August 1, 2004; 14(8): 681 - 692.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K.-Y. Tsang, C. Palena, J. Gulley, P. Arlen, and J. Schlom
A Human Cytotoxic T-Lymphocyte Epitope and Its Agonist Epitope from the Nonvariable Number of Tandem Repeat Sequence of MUC-1
Clin. Cancer Res., March 15, 2004; 10(6): 2139 - 2149.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
N. T. Marcos, A. Cruz, F. Silva, R. Almeida, L. David, U. Mandel, H. Clausen, S. von Mensdorff-Pouilly, and C. A. Reis
Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I Expression in Gastric Carcinoma Cell Lines
J. Histochem. Cytochem., June 1, 2003; 51(6): 761 - 771.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
M. V. Croce, M. T. Isla-Larrain, C. E. Rua, M. E. Rabassa, S. J. Gendler, and A. Segal-Eiras
Patterns of MUC1 Tissue Expression Defined by an Anti-MUC1 Cytoplasmic Tail Monoclonal Antibody in Breast Cancer
J. Histochem. Cytochem., June 1, 2003; 51(6): 781 - 788.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. Argueso, S. Spurr-Michaud, C. L. Russo, A. Tisdale, and I. K. Gipson
MUC16 Mucin Is Expressed by the Human Ocular Surface Epithelia and Carries the H185 Carbohydrate Epitope
Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2487 - 2495.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. Z. Rassidakis, A. Goy, L. J. Medeiros, Y. Jiang, A. Thomaides, Y. Remache, F. Cabanillas, A. H. Sarris, and F. Gilles
Prognostic Significance of MUC-1 Expression in Systemic Anaplastic Large Cell Lymphoma
Clin. Cancer Res., June 1, 2003; 9(6): 2213 - 2220.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
F. P. Paulsen, A. P. Corfield, M. Hinz, W. Hoffmann, U. Schaudig, A. B. Thale, and M. Berry
Characterization of Mucins in Human Lacrimal Sac and Nasolacrimal Duct
Invest. Ophthalmol. Vis. Sci., May 1, 2003; 44(5): 1807 - 1813.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Xia, Y. Tanaka, S. Koido, C. Liu, P. Mukherjee, S. J. Gendler, and J. Gong
Prevention of Spontaneous Breast Carcinoma by Prophylactic Vaccination with Dendritic/Tumor Fusion Cells
J. Immunol., February 15, 2003; 170(4): 1980 - 1986.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
R. W. Wilkinson, E. L. Ross, D. Ellison, W. Zimmermann, D. Snary, and S. J. Mather
Evaluation of a Transgenic Mouse Model for Anti-Human CEA Radioimmunotherapeutics
J. Nucl. Med., October 1, 2002; 43(10): 1368 - 1376.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
R L Ten Berge, F G M Snijdewint, S von Mensdorff-Pouilly, R J J Poort-Keesom, J J Oudejans, J W R Meijer, R Willemze, J Hilgers, and C J L M Meijer
MUC1 (EMA) is preferentially expressed by ALK positive anaplastic large cell lymphoma, in the normally glycosylated or only partly hypoglycosylated form
J. Clin. Pathol., December 1, 2001; 54(12): 933 - 939.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. W. Wilkinson, E. L. Ross, R. Poulsom, M. Ilyas, J. Straub, D. Snary, W. F. Bodmer, and S. J. Mather
Antibody targeting studies in a transgenic murine model of spontaneous colorectal tumors
PNAS, August 17, 2001; (2001) 181353498.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
M B Pereira, A J Dias, C A Reis, and F C Schmitt
Immunohistochemical study of the expression of MUC5AC and MUC6 in breast carcinomas and adjacent breast tissues
J. Clin. Pathol., March 1, 2001; 54(3): 210 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Meseguer, J. D. Aplin, P. Caballero-Campo, J. E. O'Connor, J. C. Martín, J. Remohí, A. Pellicer, and C. Simón
Human Endometrial Mucin MUC1 Is Up-Regulated by Progesterone and Down-Regulated In Vitro by the Human Blastocyst
Biol Reprod, February 1, 2001; 64(2): 590 - 601.
[Abstract] [Full Text]

Home page
 BloodHome page
S. P. Treon, P. Maimonis, D. Bua, G. Young, N. Raje, J. Mollick, D. Chauhan, Y.-T. Tai, T. Hideshima, Y. Shima, et al.
Elevated soluble MUC1 levels and decreased anti-MUC1 antibody levels in patients with multiple myeloma
Blood, November 1, 2000; 96(9): 3147 - 3153.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Mukherjee, A. R. Ginardi, C. S. Madsen, C. J. Sterner, M. C. Adriance, M. J. Tevethia, and S. J. Gendler
Mice with Spontaneous Pancreatic Cancer Naturally Develop MUC-1-Specific CTLs That Eradicate Tumors When Adoptively Transferred
J. Immunol., September 15, 2000; 165(6): 3451 - 3460.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
K. Kontani, O. Taguchi, T. Narita, N. Hiraiwa, S. Sawai, J. Hanaoka, M. Ichinose, N. Tezuka, S. Inoue, S. Fujino, et al.
Autologous dendritic cells or cells expressing both B7-1 and MUC1 can rescue tumor-specific cytotoxic T lymphocytes from MUC1-mediated apoptotic cell death
J. Leukoc. Biol., August 1, 2000; 68(2): 225 - 232.
[Abstract] [Full Text]

Home page
 Clin. Cancer Res.Home page
T. Gilewski, S. Adluri, G. Ragupathi, S. Zhang, T.-J. Yao, K. Panageas, M. Moynahan, A. Houghton, L. Norton, and P. O. Livingston
Vaccination of High-Risk Breast Cancer Patients with Mucin-1 (MUC1) Keyhole Limpet Hemocyanin Conjugate plus QS-21
Clin. Cancer Res., May 1, 2000; 6(5): 1693 - 1701.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
C. A. Reis, L. David, F. Carvalho, U. Mandel, C. de Bolós, E. Mirgorodskaya, H. Clausen, and M. Sobrinho–Simões
Immunohistochemical Study of the Expression of MUC6 Mucin and Co-expression of Other Secreted Mucins (MUC5AC and MUC2) in Human Gastric Carcinomas
J. Histochem. Cytochem., March 1, 2000; 48(3): 377 - 388.
[Abstract] [Full Text]

Home page
 Jpn J Clin OncolHome page
K. Matsuda, T. Masaki, T. Watanabe, J. Kitayama, H. Nagawa, T. Muto, and Y. Ajioka
Clinical Significance of MUC1 and MUC2 Mucin and p53 Protein Expression in Colorectal Carcinoma
Jpn. J. Clin. Oncol., February 1, 2000; 30(2): 89 - 94.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
T. Kokubo, K. Hashizume, H. Iwase, K. Arai, A. Tanaka, K. Toma, K. Hotta, and Y. Kobayashi
Humoral immunity against the proline-rich peptide epitope of the IgA1 hinge region in IgA nephropathy
Nephrol. Dial. Transplant., January 1, 2000; 15(1): 28 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S. Campbell, J. Larsen, M.W. Seif, T.D Allen, F. Knox, C.J.P. Jones, and J.D. Aplin
Mosaic characteristics of human endometrial epithelium in vitro: analysis of secretory markers and cell surface ultrastructure
Mol. Hum. Reprod., January 1, 2000; 6(1): 41 - 49.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
J. Burchell, R. Poulsom, A. Hanby, C. Whitehouse, L. Cooper, H. Clausen, D. Miles, and J. Taylor-Papadimitriou
An {alpha}2,3sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas
Glycobiology, December 1, 1999; 9(12): 1307 - 1311.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. V. Beum, J. Singh, M. Burdick, M. A. Hollingsworth, and P.-W. Cheng
Expression of Core 2 beta -1,6-N-Acetylglucosaminyltransferase in a Human Pancreatic Cancer Cell Line Results in Altered Expression of MUC1 Tumor-associated Epitopes
J. Biol. Chem., August 27, 1999; 274(35): 24641 - 24648.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Baruch, M.-l. Hartmann, M. Yoeli, Y. Adereth, S. Greenstein, Y. Stadler, Y. Skornik, J. Zaretsky, N. I. Smorodinsky, I. Keydar, et al.
The Breast Cancer-associated MUC1 Gene Generates Both a Receptor and Its Cognate Binding Protein
Cancer Res., April 1, 1999; 59(7): 1552 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. A. Reis, L. David, P. Correa, F. Carneiro, C. d. Bolos, E. Garcia, U. Mandel, H. Clausen, and M. Sobrinho-Simoes
Intestinal Metaplasia of Human Stomach Displays Distinct Patterns of Mucin (MUC1, MUC2, MUC5AC, and MUC6) Expression
Cancer Res., March 1, 1999; 59(5): 1003 - 1007.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Gong, D. Chen, M. Kashiwaba, Y. Li, L. Chen, H. Takeuchi, H. Qu, G. J. Rowse, S. J. Gendler, and D. Kufe
Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells
PNAS, May 26, 1998; 95(11): 6279 - 6283.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
L. B. E. Shields, C. Gercel-Taylor, C. M. Yashar, T. C. Wan, W. A. Katsanis, J. A. Spinnato, and D. D. Taylor
Induction of Immune Responses to Ovarian Tumor Antigens by Multiparity
Reproductive Sciences, November 1, 1997; 4(6): 298 - 304.
[Abstract] [PDF]

Home page
 J. Histochem. Cytochem.Home page
Y. Cao, D. Blohm, B. M. Ghadimi, P. Stosiek, P.-X. Xing, and U. Karsten
Mucins (MUC1 and MUC3) of Gastrointestinal and Breast Epithelia Reveal Different and Heterogeneous Tumor-associated Aberrations in Glycosylation
J. Histochem. Cytochem., November 1, 1997; 45(11): 1547 - 1558.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Y. Hirasawa, N. Kohno, A. Yokoyama, Y. Inoue, M. Abe, and K. Hiwada
KL-6, a Human MUC1 Mucin, Is Chemotactic for Human Fibroblasts
Am. J. Respir. Cell Mol. Biol., October 1, 1997; 17(4): 501 - 507.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. H. Wandall, H. Hassan, E. Mirgorodskaya, A. K. Kristensen, P. Roepstorff, E. P. Bennett, P. A. Nielsen, M. A. Hollingsworth, J. Burchell, J. Taylor-Papadimitriou, et al.
Substrate Specificities of Three Members of the Human UDP-N-Acetyl-alpha -D-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase Family, GalNAc-T1, -T2, and -T3
J. Biol. Chem., September 19, 1997; 272(38): 23503 - 23514.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. O. Lloyd, J. Burchell, V. Kudryashov, B. W.T. Yin, and J. Taylor-Papadimitriou
Comparison of O-Linked Carbohydrate Chains in MUC-1 Mucin from Normal Breast Epithelial Cell Lines and Breast Carcinoma Cell Lines. DEMONSTRATION OF SIMPLER AND FEWER GLYCAN CHAINS IN TUMOR CELLS
J. Biol. Chem., December 27, 1996; 271(52): 33325 - 33334.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Kovarik, P. J. Lu, N. Peat, J. Morris, and J. Taylor-Papadimitriou
Two GC Boxes (Sp1 Sites) Are Involved in Regulation of the Activity of the Epithelium-specific MUC1 Promoter
J. Biol. Chem., July 26, 1996; 271(30): 18140 - 18147.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Bergeron, S. Champetier, Hélèn. LaRue, and Y. Fradet
MAUB Is a New Mucin Antigen Associated with Bladder Cancer
J. Biol. Chem., March 22, 1996; 271(12): 6933 - 6940.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
V. Braga and S. Gendler
Modulation of Muc-1 mucin expression in the mouse uterus during the estrus cycle, early pregnancy and placentation
J. Cell Sci., January 6, 1993; 105(2): 397 - 405.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
M. Dalziel, C. Whitehouse, I. McFarlane, I. Brockhausen, S. Gschmeissner, T. Schwientek, H. Clausen, J. M. Burchell, and J. Taylor-Papadimitriou
The Relative Activities of the C2GnT1 and ST3Gal-I Glycosyltransferases Determine O-Glycan Structure and Expression of a Tumor-associated Epitope on MUC1
J. Biol. Chem., March 30, 2001; 276(14): 11007 - 11015.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. W. Wilkinson, E. L. Ross, R. Poulsom, M. Ilyas, J. Straub, D. Snary, W. F. Bodmer, and S. J. Mather
Antibody targeting studies in a transgenic murine model of spontaneous colorectal tumors
PNAS, August 28, 2001; 98(18): 10256 - 10260.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1987 by the American Association for Cancer Research.