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Blood Amino Acid Compartmentation in Mice Bearing Lewis Lung Carcinoma¹

Departament de Bioquimica i Fisiologia, Unitat de Bioquímica i Biologia Molecular B, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain

Blood amino acid compartmentation between plasma and red blood cells was studied in mice bearing the Lewis lung carcinoma. The animals showed a change in compartmentation with an increase in the concentration of most amino acids in the plasmatic fraction with the exception of glycine, glutamine, aspartate, asparagine, and taurine. This work focuses on the importance of studying the distribution of amino acids in both fractions when performing studies concerning amino acid metabolism in tumor-bearing animals.

¹ This work was supported in part with a grant from the CIRIT (Comissió Interdepartamental per a la Recerca i la Innovació Tecnològica) of the Generalitat de Catalunya.

² To whom requests for reprints should be addressed.

Received 1/21/87. Revised 5/ 7/87. Accepted 7/28/87.