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Laboratory of Human Carcinogenesis [B. I. G., J. F. L., R. R. R., E. W. G., C. C. H.], Laboratory of Chemoprevention [A. B. R.], and Laboratory of Cellular and Molecular Biology [K. C. R.], Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland 20892
Steady state mRNA levels for transforming growth factor ß, platelet-derived growth factor (PDGF) A-chain, and PDGF B-chain were measured in normal human mesothelial cells, SV40 large T-antigen expressing human mesothelial cells, and human mesothelioma cell lines. The mRNA expression level for transforming growth factor ß was similar in all three types of culture while normal human mesothelial cells secrete more transforming growth factor ß than do mesothelioma cell lines or T-antigen expressing mesothelial cells. In contrast, both PDGF A- and B-chain mRNAs are expressed at higher levels in mesothelioma cell lines than in normal human mesothelial cells. PDGF-like mitogenic activity was readily detectable in medium conditioned by a mesothelioma cell line and was undetectable in conditioned medium from normal cells. These results suggest the hypothesis that PDGF may be an autocrine growth factor in mesothelioma.
1 To whom requests for reprints should be addressed, at Building 37, Room 2C09, NIH, Bethesda, MD 20892.
2 Current address: Baltimore VA Medical Center, 3900 Loch Raven Blvd., Baltimore, MD 21218.
Received 4/28/87. Revised 8/12/87. Accepted 9/ 8/87.
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