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and ß and the Epidermal Growth Factor Receptor by Human Tumors
Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080 [R. D., D. V. G., A. U., T. S. B., W. H. B.]; Department of Clinical Immunology and Biological Therapy, M. D. Anderson Hospital, Texas Medical Center, Houston, Texas 77032 [J. U. G.]; and University of California Urology Service, Veterans Administration Medical Center, San Francisco, California 94121 [R. D. W.]
Human tumors and tumor cell lines were analyzed for the presence of mRNA coding for transforming growth factors 
and ß (TGF- and -ß) and the epidermal growth factor receptor. TGF- mRNA was not detectable in hematopoietic tumor cell lines but was found in a variety of solid tumor cells, particularly carcinomas. Many of the tumors that contained TGF- mRNA also expressed high levels of epidermal growth factor receptor mRNA. The concentration of TGF- in the media of several tumor cell lines did not necessarily correlate with TGF- mRNA levels, as a substantial fraction of TGF- can remain cell associated. The levels of TGF- mRNA in tumor cell lines and tumor specimens were variable, but higher in tumors than in the adjacent normal tissues.
1 To whom requests for reprints should be addressed at present address: Center for Thrombosis and Vascular Research, University of Leuven, Gasthuisberg, B-3000 Leuven, Belgium.
2 Present address: Department of Urology, University of Iowa Hospital, Iowa City, IA 52242.
Received 8/25/86. Revised 10/29/86. Accepted 10/30/86.
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|
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|
|
|
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|
|
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|
|
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
D. Wang, T. H. Shin, and J. E. Kudlow Transcription Factor AP-2 Controls Transcription of the Human Transforming Growth Factor-alpha Gene J. Biol. Chem., May 30, 1997; 272(22): 14244 - 14250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
H. C. Pitot, Y. P Dragan, J. Teeguarden, S. Hsia, and H. Campbell Quantitation of Multistage Carcinogenesis in Rat Liver Toxicol Pathol, January 1, 1996; 24(1): 119 - 128. [Abstract] [PDF]
|
|
|
|
 |
|
 B. A. Burtness Oncology and Hematology JAMA, June 7, 1995; 273(21): 1702 - 1703. [Abstract] [PDF]
|
|
|
|
|
|
E. Miyoshi, A. Nishikawa, Y. Ihara, H. Saito, N. Uozumi, N. Hayashi, H. Fusamoto, T. Kamada, and N. Taniguchi Transforming Growth Factor beta Up-regulates Expression of the N-Acetylglucosaminyltransferase V Gene in Mouse Melanoma Cells J. Biol. Chem., March 17, 1995; 270(11): 6216 - 6220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Reneker, D. Silversides, K Patel, and P. Overbeek TGF alpha can act as a chemoattractant to perioptic mesenchymal cells in developing mouse eyes Development, January 6, 1995; 121(6): 1669 - 1680. [Abstract] [PDF]
|
|
|
|
|
|
R Sharp, M. Babyatsky, H Takagi, S Tagerud, T. Wang, D. Bockman, S. Brand, and G Merlino Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice Development, January 1, 1995; 121(1): 149 - 161. [Abstract] [PDF]
|
|
|
|
 |
|
 T. S. Frank, J. C. Reed, and J. S. J. Brooks Absence of Expression of c-sis and Transforming Growth Factor-{beta} mRNA in Malignant Fibrous Histiocytoma International Journal of Surgical Pathology, October 1, 1993; 1(2): 117 - 121. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Ho, T. Horn, and E. Finzi Transforming Growth Factor {alpha} Expression Helps to Distinguish Keratoacanthomas From Squamous Cell Carcinomas Arch Dermatol, August 1, 1991; 127(8): 1167 - 1171. [Abstract] [PDF]
|
|
|
|
|
|
R. Todd, M.Y. Chou, K. Matossian, G.T. Gallagher, R.B. Donoff, and D.T.W. Wong Cellular Sources of Transforming Growth Factor-Alpha in Human Oral Cancer Journal of Dental Research, May 1, 1991; 70(5): 917 - 923. [Abstract] [PDF]
|
|
|
|
 |
|
 R Vassar and E Fuchs Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes & Dev., May 1, 1991; 5(5): 714 - 727. [Abstract] [PDF]
|
|
|
|
 |
|
 A Wells, J. Welsh, C. Lazar, H. Wiley, G. Gill, and M. Rosenfeld Ligand-induced transformation by a noninternalizing epidermal growth factor receptor Science, February 23, 1990; 247(4945): 962 - 964. [Abstract] [PDF]
|
|
|
|
|
|
C. D. Albright, R. T. Jones, P. M. Grimley, and J. H. Resau Intercellular Communication in Bronchial Epithelial Cells: Review of Evidence for a Possible Role in Lung Carcinogenesis Toxicol Pathol, February 1, 1990; 18(2): 324 - 343. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Mina, E. J. Kollar, J. A. Bishop, and D. H. Rohrbach Interaction between The Neural Crest and Extracellular Matrix Proteins in Craniofacial Skeletogenesis Critical Reviews in Oral Biology & Medicine, January 1, 1990; 1(2): 79 - 87. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
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|
|
|
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| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
