This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Reddy, B. S. Articles by Maruyama, H. Search for Related Content PubMed PubMed Citation Articles by Reddy, B. S. Articles by Maruyama, H.

Effect of Restricted Caloric Intake on Azoxymethane-induced Colon Tumor Incidence in Male F344 Rats¹

Divisions of Nutrition and Endocrinology [B. S. R.] and Experimental Pathology and Toxicology [C. X. W., H. M.], Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York 10595

The effect of 30% caloric restriction on azoxymethane (AOM)-induced colon carcinogenesis was investigated in male F344 rats. Starting at 5 weeks of age, groups of animals were fed ad libitum a high-fat (23.5%) semipurified diet. At 7 weeks of age, all animals except the vehicle-treated groups were s.c. injected with AOM (15 mg/kg body wt, once weekly for 2 weeks). Four days after the second AOM injection, groups of animals were continued on high-fat diet and fed ad libitum (ad libitum group) whereas other groups were restricted to 70% of total calories (calorie-restricted group) consumed by the ad libitum group, but received same amounts of fiber, vitamins, and minerals. Thirty-two weeks after AOM injections, all animals were necropsied. The animals in the calorie-restricted group developed significantly fewer colon tumors and had a lower colon tumor incidence than did the rats in the ad libitum group. The size of colon tumors was also reduced in the calorie-restricted group.

¹ This investigation was supported in part by USPHS Grants CA-17613 and CA-37663 from the National Cancer Institute. Animals were maintained under the guidelines set forth in the "Guide for the Care and Use of Laboratory Animal Resources" by the National Research Council.

² To whom requests for reprints should be addressed, at Naylor Dana Institute, American Health Foundation, Nutrition and Endocrinology, Dana Road, Valhalla, NY 10595.

Received 9/22/86. Revised 11/19/86. Accepted 12/ 4/86.

This article has been cited by other articles:

				A. A. Moghaddam, M. Woodward, and R. Huxley Obesity and Risk of Colorectal Cancer: A Meta-analysis of 31 Studies with 70,000 Events Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2533 - 2547. [Abstract] [Full Text] [PDF]

				Z. Kabir and L. Clancy Global trends in adenocarcinomas and obesity: an epidemiologic link? Int. J. Epidemiol., August 1, 2003; 32(4): 661 - 662. [Full Text] [PDF]

				D. L. Zoran, N. D. Turner, S. S. Taddeo, R. S. Chapkin, and J. R. Lupton Wheat Bran Diet Reduces Tumor Incidence in a Rat Model of Colon Cancer Independent of Effects on Distal Luminal Butyrate Concentrations J. Nutr., November 1, 1997; 127(11): 2217 - 2225. [Abstract] [Full Text]

				H. S. Wasan, M. Novelli, J. Bee, and W. F. Bodmer Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice PNAS, April 1, 1997; 94(7): 3308 - 3313. [Abstract] [Full Text] [PDF]