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Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch [L. T. M., U. N., A. W. B.], and Higginbotham Neuroscience Research Laboratory [A. H. K.], P. O. Royal Melbourne Hospital, Victoria 3050, Australia
Primary brain tumors of glial origin often overexpress epidermal growth factor receptors (EGF-Rs). This may be associated with amplification of the EGF-R gene. We have examined tissue from 23 glioblastoma multiforme tumors and found amplification and rearrangement of the EGF-R gene in four of these. The cytoplasmic domain of the EGF-R gene was invariably amplified in these four tumors, while the epidermal growth factor binding domain was not uniformly amplified in three of these tumors.
Western blot analysis of the EGF-R protein revealed high levels of a truncated EGF-R protein in two of the four tumors with EGF-R gene amplification.
1 Supported by a National Health and Medical Research Council Postgraduate Scholarship. To whom requests for reprints should be addressed.
Received 11/ 2/87. Accepted 2/15/88.
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