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Infrequent Loss of Chromosomal Heterozygosity in Human Stomach Cancer¹

National Cancer Center Research Institute, 1-1, Tsukiji 5-Chome, Chuo-ku, Tokyo 104 [M. W., J. Y., T. S., M. T.]; and Department of Medicine, Tokyo Women's Medical College, 1, Kawada-cho 8-chome, Shinjuku-ku, Tokyo 162 [M. W., H. M.]; Japan

By molecular genetic approach using polymorphic DNA markers which detect allelic deletion at specific chromosomal loci, we analyzed 30 human stomach cancers for possible loss of chromosomal heterozygosity. We analyzed 25 loci on 18 different chromosomes covering regions frequently deleted in several types of cancers. Loss of chromosomal heterozygosity was observed only in five of 30 cases examined, and it was infrequently detected at 10 loci on seven different chromosomes including chromosome 1 in two of 12 cases, chromosome 12 in one of four cases and chromosome 13 in three of 27 cases. It was also observed at loci on chromosomes 11, 14, 16, and 19 with very low frequency (<10%), but not on other chromosomes: chromosomes 3, 5, 6, 9, 10, 15, 17, 18, 20, and 22. Thus, in human stomach cancer, loss of heterozygosity occurs infrequently even at chromosomal loci often deleted in other types of cancers.

¹ This work was supported in part by a Grant-in-Aid for a Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health and Welfare of Japan, a Grant-in-Aid from the Ministry of Health and Welfare of Japan and a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan.

² To whom requests for reprints should be addressed, at Genetics Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104.

Received 1/19/88. Accepted 3/ 4/88.

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