This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Pakala, R. Articles by Bachrach, U. Search for Related Content PubMed PubMed Citation Articles by Pakala, R. Articles by Bachrach, U.

Polyamine Metabolism and Interconversion in NIH 3T3 and ras-transfected NIH 3T3 Cells

Department of Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem 91010, Israel

The effect of transfection of NIH 3T3 cells by the human ras (c-Ha-ras-1) oncogene on uptake, interconversion, and excretion of polyamines was studied. Uptake and interconversion of spermidine were higher in the ras-transfected cells. Acetylpolyamines were excreted into the medium by the ras-transfected cells, whereas they were retained by NIH 3T3 cells. In addition to acetylpolyamines, some unknown polyamine conjugates occurred in the ras-transfected cells.

¹ To whom requests for reprints should be addressed.

Received 4/21/87. Revised 7/17/87. Revised 11/ 9/87. Revised 2/ 5/88. Accepted 2/16/88.