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Metabolism of the Z and E Isomers of N-Nitroso-N-methyl-(2-oxopropyl)amine by Rat Hepatocytes¹

NCI-Frederick Cancer Research Facility, Basic Research Program, Frederick, Maryland 21701

The metabolism of N-nitroso-N-methyl-N-(2-oxopropyl)amine was examined using freshly isolated hepatocytes from Fischer 344 rats. As determined by high performance liquid chromatography, it was found that the E isomer was preferentially metabolized when the parent mixture was used. When the two isomers were studied separately, the E isomer was efficiently metabolized in the hepatocytic system, whereas the Z isomer was not. The kinetics of disappearance of the Z isomer during metabolism was identical to that for the reequilibration of the Z isomer to the mixture of isomers in the absence of a metabolizing system.

¹ Research sponsored by the National Cancer Institute, Department of Health and Human Services, under Contract NO1-CO-23909 with Bionetics Research, Inc. The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U. S. Government.

² To whom requests for reprints should be addressed, at National Cancer Institute, Frederick Cancer Research Facility, P. O. Box B, Frederick, MD 21701.

Received 8/10/87. Revised 2/17/88. Accepted 3/15/88.

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