This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Romerdahl, C. A. Articles by Kripke, M. L. Search for Related Content PubMed PubMed Citation Articles by Romerdahl, C. A. Articles by Kripke, M. L.

Effect of Ultraviolet-B Radiation on the in Vivo Growth of Murine Melanoma Cells¹

Departments of Immunology [C. A. R., M. L. K., C. D.] and Cell Biology [I. J. F.], University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

The role of UV radiation in the development of malignant melanoma has yet to be clearly defined. The purpose of these studies was to determine whether UV irradiation of mice produces local or systemic alterations that increase the in vivo growth of transplanted melanoma cells. K-1735 melanoma cells were injected into the external ears of syngeneic C3H mice. UV irradiation of the mice before or at the time of injection of the melanoma cells accelerated the appearance of the tumors. The effect was observed when melanoma cells were transplanted directly into the site of UV irradiation, but not when they were injected into an unirradiated site. The initial survival of radiolabeled melanoma cells at the site of inoculation was not altered by UV irradiation of the host, suggesting that the accelerated appearance of tumors was due to an increase in the clonogenic potential of cells injected into UV-irradiated skin. The effect of UV irradiation on the development of other syngeneic tumors was also investigated. The outgrowth of a second melanoma was also accelerated in UV-irradiated mice, whereas the growth of a UV-induced fibrosarcoma, a methylcholanthrene-induced fibrosarcoma, and a spontaneous hepatocarcinoma was not affected. These results suggest that, in addition to its carcinogenic activity, UV radiation may contribute to the incidence of cutaneous melanoma because of a local effect on the skin that stimulates melanoma development.

¹ This research was supported by Grant R-812607 from the United States Environmental Protection Agency.

² A Tesoro Petroleum Corp. postdoctoral fellow. Present address: Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.

³ To whom requests for reprints should be addressed.

Received 9/ 1/87. Revised 4/ 7/88. Accepted 4/11/88.

This article has been cited by other articles:

				D. Jean, J. E. Gershenwald, S. Huang, M. Luca, M. J. Hudson, M. A. Tainsky, and M. Bar-Eli Loss of AP-2 Results in Up-regulation of MCAM/MUC18 and an Increase in Tumor Growth and Metastasis of Human Melanoma Cells J. Biol. Chem., June 26, 1998; 273(26): 16501 - 16508. [Abstract] [Full Text] [PDF]

				J. Adami, M. Frisch, J. Yuen, B. Glimelius, and M. Melbye Evidence of an association between non-Hodgkin's lymphoma and skin cancer BMJ, June 10, 1995; 310(6993): 1491 - 1495. [Abstract] [Full Text]