This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lönn, U. Articles by Lönn, S. Search for Related Content PubMed PubMed Citation Articles by Lönn, U. Articles by Lönn, S.

Increased Levels of DNA Lesions Induced by Leucovorin-5-Fluoropyrimidine in Human Colon Adenocarcinoma¹

Radiumhemmet, Karolinska Hospital and Department of Histology, Karolinska Institutet, Stockholm, Sweden

Leucovorin augments the growth inhibitory effect of 5-fluoropyrimidines on neoplastic cells. The effect is paralleled by much higher levels of DNA fragmentation than in cells treated with 5-fluoropyrimidines alone at the same concentration. The lesions are induced by a mechanism independent of incorporation of the drug into DNA, in all probability due to reduced repair of DNA lesions induced independently of the drug treatment. Thymidine added after the treatment with fluoropyrimidines partly rescues the cells and reduces the level of DNA fragmentation.

¹ This work was supported by grants from the Stockholm Cancer Society and Karolinska Institute.

² To whom requests for reprints should be addressed, at Radiumhemmet, Karolinska Hospital, PO Box 60 500, S-104 01 Stockholm, Sweden.

Received 1/12/88. Revised 4/29/88. Accepted 5/ 4/88.

This article has been cited by other articles:

				J. Ciccolini, P. Cuq, A. Evrard, S. Giacometti, A. Pelegrin, C. Aubert, J.-P. Cano, and A. Iliadis Combination of Thymidine Phosphorylase Gene Transfer and Deoxyinosine Treatment Greatly Enhances 5-Fluorouracil Antitumor Activity in Vitro and in Vivo Mol. Cancer Ther., December 1, 2001; 1(2): 133 - 139. [Abstract] [Full Text] [PDF]