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Doxycycline in Combination Chemotherapy of a Rat Leukemia¹

Laboratory of Physiological Chemistry, State University Groningen, The Netherlands

Inhibition of mitochondrial protein synthesis by doxycycline (DC), a tetracycline analogue, has significant antitumor effects in several tumor systems. In the present study, the effects of continuous DC treatment combined with intermittent administration of Adriamycin or 1-ß-D-arabinofuranosyl cytosine on the growth of a rat leukemia were investigated. The presence of DC retards tumor relapse after 1-ß-D-arabinofuranosyl cytosine or Adriamycin treatment significantly. DC may therefore be of value in several modalities of antitumor treatment.

¹ This work is supported in part by a grant from the Dutch Foundation for Cancer Research, the Koningin Wilhelmina Fonds.

² Present address: Laboratory of Biochemistry, University of Amsterdam, B. C. P. Jansen Institute, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands. To whom requests for reprints should be addressed.

Received 5/13/88. Revised 8/22/88. Accepted 9/ 6/88.