This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gensler, H. L. Search for Related Content PubMed PubMed Citation Articles by Gensler, H. L.

Enhancement of Chemical Carcinogenesis in Mice by Systemic Effects of Ultraviolet Irradiation¹

Department of Radiation Oncology and Cancer Center, University of Arizona, College of Medicine, Tucson, Arizona 85724

The present study was designed to determine the systemic influence of ultraviolet (UVB) irradiation upon subsequent carcinogenesis induced by benzo(a)pyrene. The source of UV irradiation consisted of six Westinghouse FS-40 fluorescent sunlamps. Female BALB/c mice received five 30-min dorsal UVB radiation treatments per week for 13 wk. At the end of 13 wk, irradiated and unirradiated mice received ventral applications of 0.1 or 1.0 mg of benzo(a)pyrene twice weekly for 20 or 10 wk, respectively. At 18 wk after the first benzo(a)pyrene treatment, mice receiving 0-, 0.1-, or 1.0-mg benzo(a)pyrene treatments bore 0, 12, or 29 tumors per group of 18 mice, respectively. Tumor-free survival was significantly shortened in the UV-irradiated hosts as compared with unirradiated hosts, as analyzed by the Kaplan-Meier method of survival analysis. Therefore, ultraviolet irradiation induced a systemic effect which enhanced subsequent tumor induction by benzo(a)pyrene in a manner which was dependent on the dose of benzo(a)pyrene.

¹ This investigation was supported by NIH Grants CA-27502 and CA-44504.

Received 7/31/87. Revised 10/29/87. Accepted 11/ 4/87.

This article has been cited by other articles:

				W. B. Bair III, N. Hart, J. Einspahr, G. Liu, Z. Dong, D. Alberts, and G. T. Bowden Inhibitory Effects of Sodium Salicylate and Acetylsalicylic Acid on UVB-induced Mouse Skin Carcinogenesis Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1645 - 1652. [Abstract] [Full Text] [PDF]