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erbA-related Sequence Coding for DNA-binding Hormone Receptor Localized to Chromosome 3p21–3p25 and Deleted in Small Cell Lung Carcinoma¹

Institut du Cancer de Montréal, Montreal, Quebec, Canada H2L 4M1

Small-cell lung carcinoma (SCLC) is characterized by a consensus deletion in the short arm of chromosome 3. Using a panel of cell lines and somatic cell hybrids containing various rearrangements involving chromosome 3, we have localized the erbAß sequence (which codes for a thyroid hormone receptor) to the region 3p21 3p25 which overlaps the consensus deletion in SCLC. Moreover, we have shown by Southern blot analysis that at least one copy of the erbAß sequence is deleted in all six SCLCs so far studied. Normalized ratios of hybridization intensities of the erbAß probe to intensities of probes for somatostatin (3q28) and raf(3p24–25) ranged from 0.28 to 0.56 and 0.32 to 0.71, respectively, in the six tumors and tumor lines. In view of the importance of the role these genes are known or suspected to play in biological regulation, our results suggest that the erbAß sequence is a candidate for a recessive oncogene involved in the genesis of SCLC.

¹ Supported by the National Cancer Institute of Canada, The Medical Research Council of Canada, and the Fonds de Recherche en Santé du Québec.

² Present address: Department of Hematology, Flinders University of South Australia, Adelaide, Australia.

³ To whom requests for reprints should be addressed, at Institut du Cancer de Montréal, 1560 est, rue Sherbrooke, Montréal, Québec, Canada H2L 4MI.

Received 7/14/87. Revised 10/23/87. Accepted 10/29/87.

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