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[Cancer Research 48, 759-774, February 15, 1988]
© 1988 American Association for Cancer Research
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Polyamine Metabolism and Its Importance in Neoplastic Growth and as a Target for Chemotherapy1

Anthony E. Pegg

Departments of Physiology and Pharmacology and Cancer Research Center, Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033

The polyamine-biosynthetic pathway represents an inviting target for the development of agents inhibiting carcinogenesis and tumor growth. Polyamines play an essential role in the proliferation and development of mammalian cells. Deranged polyamine metabolism may be an important factor in carcinogenesis. Depletion of polyamines inhibits growth of neoplastic cells in vitro and in animal models. Several different classes of other anticancer agents may under some conditions exert enhanced effects when polyamine levels are depleted. Some suitable inhibitors of polyamine production are currently available and other promising compounds are presently being tested. It should soon prove possible to block polyamine biosynthesis at every step in the pathway. The use of these inhibitors alone and combined either with each other or with other antitumor agents will enable a full examination of the potential of this approach.

1 Research on polyamines in the author's laboratory was supported by Grants CA-18138, GM-26290, and CA-37606 from the NIH.

Received 10/14/87. Accepted 11/10/87.




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