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Enhancement of Cytogenetic Damage and of Antineoplastic Effect by Caffeine in Ehrlich Ascites Tumor Cells Treated with Cyclophosphamide in Vivo

Department of Medicinal Biology and Genetics, Faculty of Medicine, Aristotelian University, Thessaloniki 54006, Greece

Enhanced cytogenetic damage by cyclophosphamide (CP) was observed when Ehrlich ascites tumor cells were exposed in vivo to nontoxic concentrations of caffeine. One h before i.p. injection of 5-bromodeoxy-uridine adsorbed to activated charcoal Ehrlich ascites tumor-bearing mice treated i.p. with CP appear to have a dose-dependent increase in sister chromatid exchange rates and cell division delays.

Caffeine increased the survival time of the Ehrlich ascites tumor-bearing mice treated with CP and markedly reduced the ascitic volume. Therefore, the in vivo antitumor effect by CP in conjunction with caffeine appears to correlate well with the in vivo synergistic effect on cytogenetic damage caused by the combined CP plus caffeine treatment.

¹ To whom requests for reprints should be addressed.

Received 7/ 7/87. Revised 10/27/87. Accepted 11/23/87.

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