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Contribution by Host Tissues to Circulating Glutamine in Mice Inoculated with Ehrlich Ascites Tumor Cells¹

Departmento de Bioquímica, Facultad de Ciencias, Universidad de Málaga, Spain

Twenty-four h after tumor transplantation increases of free glutamine in plasma, liver, and kidney occurred simultaneously with the exponential phase of tumor growth. Kidney and muscle glutamine synthetase also increased in the first 2 days following tumor transplantation, while kidney and liver glutaminases decreased. The levels of free glutamine in plasma and tissues, and the activities of glutamine synthetase and glutaminase, tended to approach normal values in the last days of life of the tumor-transplanted animals. Eleven days after transplantation, liver glutamine synthetase activity diminished. The results are discussed in terms of a glutamate/glutamine intercellular cycle which could augment the circulating glutamine, the main source of nitrogen for tumor cells.

¹ This study was supported by Grant 962/84 from the Comisión Asesora de Investigación Científica y Técnica and Grant 85/1269 from the Fondo de Investigaciones Sanitarias.

² To whom requests for reprints should be addressed, at Departamento de Bioquímica, Universidad de Málaga, Facultad de Ciencias, 29071 Málaga, Spain.

Received 6/13/86. Revised 3/27/87. Revised 7/27/87. Revised 11/30/87. Accepted 12/ 9/87.

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