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Dual Effect of Transforming Growth Factor ß on Rat Thyroid Cells: Inhibition of Thyrotropin-induced Proliferation and Reduction of Thyroid-specific Differentiation Markers¹

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia e Oncologia Sperimentale del C.N.R., II Facoltà di Medicina e Chirurgia, Via S. Pansini 5, Naples, Italy

Transforming growth factor ß (TGFß) is now known to have a number of effects other than inducing phenotypic transformation of fibroblastic cells: TGFß controls proliferation, differentiation, and other functions in many cell types. In this paper we have analyzed the action of TGFß₁ on a system of differentiated epithelial rat thyroid cells in culture (FRTL5), which depend on the addition of thyrotropin for their growth. TGFß₁ is able to inhibit the growth of thyroid cells by reducing cell response to thyrotropin. Moreover, in analogy to the effect produced upon other differentiated cells in culture, such as myoblasts and adipocytes, TGFß₁ modulates the expression of FRTL5-specific thyroid markers, reducing thyroglobulin biosynthesis and the ability to concentrate the iodide.

¹ This work was supported by Progetto Finalizzato Oncologia and Ingegneria Genetica del Consiglio Nazionale delle Ricerche and by the Associazione Italiana sulla Ricerca sul Cancro.

Received 9/28/88. Revised 2/13/89. Accepted 2/24/89.

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