This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nathanson, S. D. Articles by Jacobsen, G. Search for Related Content PubMed PubMed Citation Articles by Nathanson, S. D. Articles by Jacobsen, G.

Relationship of Spontaneous Regional Lymph Node Metastases to Dose of Local Irradiation of Primary B16 Melanomas¹

The Departments of Surgery, Neurology, and Biostatistics, Henry Ford Hospital, Detroit, Michigan 48202

We evaluated the effects of local X-irradiation on microscopic or small macroscopic primary melanomas in the feet of C57BL/6 mice and the subsequent development of spontaneous femoral lymph node (LN) metastases. Doses of 30, 40, 55, 62.5, or 72.5 Gy often cured the foot tumor and metastases to regional femoral lymph nodes were relatively uncommon. Doses of 3.75, 7.5, 10, 15, and 20 Gy were associated with a dose-dependent regrowth delay of the foot tumor treated at microscopic size. Foot melanomas that were not cured spread to regional femoral LNs more frequently (P < 0.001). The relative risk of developing femoral LN metastasis increased 2.55 times for each 1-mm increase in the anteroposterior diameter of the primary foot tumor in mice with 20 days of primary tumor exposure and increased 4.87 times for each 1-mm increase in mice with 100 days of primary tumor exposure. Although tumors treated with subcurative doses of irradiation had a longer period of time to metastasize to regional LNs for each 1-mm increase in primary tumor size, this variable alone did not account for the increased incidence of metastasis seen with irradiation.

¹ This investigation was supported by NIH-NCI Ca43709-01.

² To whom reprint requests should be addressed, at Department of Surgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202.

Received 2/23/88. Revised 3/27/89. Revised 5/10/89. Accepted 5/18/89.

This article has been cited by other articles:

				A. Ito, Y.-i. Koma, K. Watabe, T. Nagano, Y. Endo, H. Nojima, and Y. Kitamura A Truncated Isoform of the Protein Phosphatase 2A B56{gamma} Regulatory Subunit May Promote Genetic Instability and Cause Tumor Progression Am. J. Pathol., January 1, 2003; 162(1): 81 - 91. [Abstract] [Full Text] [PDF]