This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hong, F. Articles by Mayhew, E. Search for Related Content PubMed PubMed Citation Articles by Hong, F. Articles by Mayhew, E.

Therapy of Central Nervous System Leukemia in Mice by Liposome-entrapped 1-ß-D-Arabinofuranosylcytosine¹

Departments of Experimental Pathology [F. H., E. M.] and Experimental Therapeutics [E. M.], Roswell Park Memorial Institute,^,4 Buffalo, New York 14263

Studies were undertaken to determine the therapeutic effects of liposome-encapsulated 1-ß-D-arabinofuranosylcytosine (lip-ara-C) against intracranial L1210 leukemia. The effects of administration route, drug dosage, liposome type, and tumor load on therapeutic efficacy were also studied. One hundred % mice were cured after a single intracranial 40 mg/kg dose of lip-ara-C, dependent on tumor load. Intracranial lip-ara-C was more effective than i.v. lip-ara-C. A single i.v. dose of lip-ara-C was therapeutically superior to 5-day i.v. infusion of the free drug. Intracranial or i.v. lip-ara-C at therapeutic doses resulted in less systemic toxicity than i.v. infusion of free ara-C, suggesting possible use of lip-ara-C as an adjunct to treatment of central nervous system leukemia.

¹ This work was partially supported by a grant from the Association for Research on Childhood Cancer.

² Current address: Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.

³ To whom requests for reprints should be addressed.

⁴ A unit of the New York State Department of Health

Received 2/ 3/89. Revised 5/15/89. Accepted 5/26/89.