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Feline Lymphomas: Immunological and Cytochemical Characterization¹

Department of Veterinary Pathobiology and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 [J. L. R., G. J. K., K. L. H.]; Division of Hematology, School of Medicine, University of Washington, Seattle, Washington 98195 [J. L. A.]; Laboratory of Veterinary Oncology, Memorial Sloan Kettering, New York, New York 10021 [W. D. H.]; Basic Research Program, Litton Bionetics, Frederick Cancer Research Facility, Frederick, Maryland 21701 [J. N. I.]; and Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701 [S. J. O.]

The immunological and cytochemical phenotypes of five primary feline lymphomas and six feline lymphoma lines are reported. Thymic lymphomas induced by the Rickard strain of FeLV (FeLV-R) are of prothymocyte or (immature) cortical thymocyte origin, as these express terminal deoxynucleotidyl transferase, the guinea pig erythrocyte rosette receptor, Ia antigens, partial cortisone sensitivity, and nonspecific esterase. Lymphomas associated with other strains of FeLV form rosettes with guinea pig erythrocytes, frequently have Ia antigens and cytoplasmic nonspecific esterase, and probably originate from helper T-cells, monocyte/macrophages, or null cells. These data belie previous conclusions that FeLV leukemogenesis is restricted to mature T-cells; rather, the considerable heterogeneity in the surface and cytochemical phenotype of feline lymphomas probably reflects transformation of multipotent lymphoid or monocytoid precursors in the bone marrow by FeLV.

¹ Supported by R01 CA-35747, U01 AI-25722, and Program Project Grant CA-16673.

² Scholar of the Leukemia Society of America, Inc.

Received 5/12/88. Revised 10/ 7/88. Accepted 10/18/88.

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