This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ichikawa, T. Articles by Shimazaki, J. Search for Related Content PubMed PubMed Citation Articles by Ichikawa, T. Articles by Shimazaki, J.

Progression and Selection in Heterogeneous Tumor Composed of Androgen-responsive Shionogi Carcinoma 115 and Its Autonomous Subline (Chiba Subline 2)¹

Department of Urology, School of Medicine, Chiba University [T. I., S. A., J. S.], Chiba-shi 280, and National Institute of Radiological Sciences [I. H.], Chiba-shi 260, Japan

Shionogi Carcinoma 115 (SC 115) is an androgen-dependent mouse tumor, and Chiba subline 2 (CS 2) is its androgen-independent subline which differs from SC 115 in cell size, amount of androgen receptors, and karyotype. To shed light on the mechanism of clonal selection of androgen-independent tumors, mixed tumors with SC 115 and CS 2 were prepared, and growth of these tumors was examined in vivo and in vitro. When the mixed tumor was transplanted in mice, CS 2 showed a predominant growth over SC 115. In a culture of mixed tumor cells, however, CS 2 showed no selective growth advantage. The suppressive interaction which occurred in vivo was due neither to transferable substances, nor to some immunological factor(s). It may be, at least partially, attributable to necrosis formation in SC 115, which developed with an increase in the size of the tumor.

¹ Supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science, and Culture (62010012); from the Ministry of Health and Welfare (62-40); and for scientific research from the Ministry of Education, Science, and Culture (62480333), Japan.

² To whom requests for reprints should be addressed.

Received 3/ 1/88. Revised 6/20/88. Revised 9/30/88. Accepted 10/10/88.

This article has been cited by other articles:

				Y. Watabe, H. Kuramochi, Y. Furuya, N. Inagaki, S. Seino, S. Kimura, and J. Shimazaki Identification of Histone H2A.X as a Growth Factor Secreted by an Androgen-independent Subline of Mouse Mammary Carcinoma Cells J. Biol. Chem., October 11, 1996; 271(41): 25126 - 25130. [Abstract] [Full Text] [PDF]