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Cytogenetic Analysis of Ten Human Seminomas¹

Departments of Human Genetics [S. M. M. J. C., B. d. J., R. S., G. J. t. M.], Pathology [J. W. O., A. D.], and Surgical Oncology [H. S. K.], State University of Groningen, The Netherlands

A cytogenetic analysis of ten seminomas has been carried out after direct harvesting of the tumor cells. Modal chromosome numbers ranged from 63 to 112. These numbers were in agreement with flow cytometric determination of the DNA content of the tumors. Eight tumors had at least one copy of an i(12p) among other chromosomal abnormalities. Two seminomas lacked the i(12p).

¹ This work was supported by Grant GUKC 84-06 of the Netherlands Cancer Foundation (KWF), by the Jan Kornelis de Cock Stichting, and by an institutional grant from the Hubrecht Laboratorium, Utrecht, The Netherlands.

² Member of the staff of the Department of Medical Genetics, Medical Faculty of Oporto, Oporto, Portugal.

³ To whom requests for reprints should be addressed, at Department of Human Genetics, State University of Groningen, Antonius Deusinglaan 4, 9713 AW Groningen, The Netherlands.

Received 2/18/88. Revised 6/10/88. Revised 9/27/88. Accepted 10/10/88.

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