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Chromosomal Changes in Human Primary Testicular Nonseminomatous Germ Cell Tumors¹

Departments of Human Genetics [S. M. M. J. C., B. de J., R. S., G. J. te M.], Pathology [J. W. O., A. D.], Surgical Oncology [H. S. K.], and Medical Oncology [D. T. S.], State University of Groningen, Antonius Deusinglaan 4, 9713 AW Groningen, The Netherlands

A cytogenetic analysis of 14 primary testicular nonseminomatous germ cell tumors has been carried out after short term tissue culture. The modal chromosome numbers ranged from 53 to 113, in agreement with flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. Two tumors, however, lacked that marker. Some chromosomes are apparently overrepresented, whereas others are underrepresented, although some differences between seminomas and nonseminomas were noticed.

¹ This work was supported by Grant GUKC 84-06 of the Netherlands Cancer Foundation (KWF), by the Jan Kornelis de Cock Stichting, and by an institutional grant from the Hubrecht Laboratorium, Utrecht, The Netherlands.

² Member of the staff of the Department of Medical Genetics, Medical Faculty of Oporto, Portugal.

³ To whom requests for reprints should be addressed.

Received 6/13/88. Revised 1/13/89. Revised 5/22/89. Accepted 7/ 5/89.

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