This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kovacs, G. Articles by Frisch, S. Search for Related Content PubMed PubMed Citation Articles by Kovacs, G. Articles by Frisch, S.

Clonal Chromosome Abnormalities in Tumor Cells from Patients with Sporadic Renal Cell Carcinomas¹

Laboratory of Cytogenetics, Institute of Pathology, Hannover Medical School, Hannover, Federal Republic of Germany

The karyotype of 75 sporadic, nonpapillary renal cell carcinomas was analyzed using chromosome banding techniques. Sixty-five tumors had near-diploid stemlines, and ten had near-triploid or near-tetraploid stemlines. Aberration of chromosome 3 was detected in 71 cases. The nonrandom changes on chromosome 3 were monosomy 3, terminal deletions, or unbalanced translocations; the 3p13-pter segment was identified as the minimal common deletion. The rearrangement of chromosome 3p was the only karyotype change in 13 tumors. Abnormalities of chromosome 5 resulting in trisomy for the 5q22-qter region were found in 36 cases, while the loss of 14q22-qter segment was observed in 34 tumors. Trisomy for chromosome 7 was detected in 17 cases, and monosomy 8 and 9 occurred 14 times each. Our data show that more than one specific chromosomal site may be involved in the development of human renal cell carcinomas.

¹ This research was supported by a grant from the Deutsche Forschungsgemeinschaft (DFG Ko 841/3-2).

² To whom requests for reprints should be addressed, at the Institute of Pathology, Albert-Ludwigs-University, Albert Str. 19, D-7800 Freiburg, F.R.G.

Received 8/12/88. Revised 10/24/88. Accepted 10/31/88.

This article has been cited by other articles:

				H. Sultmann, A. v. Heydebreck, W. Huber, R. Kuner, A. Buness, M. Vogt, B. Gunawan, M. Vingron, L. Fuzesi, and A. Poustka Gene Expression in Kidney Cancer Is Associated with Cytogenetic Abnormalities, Metastasis Formation, and Patient Survival Clin. Cancer Res., January 15, 2005; 11(2): 646 - 655. [Abstract] [Full Text] [PDF]

				M. L. Gonzalgo, S. Yegnasubramanian, G. Yan, C. G. Rogers, T. L. Nicol, W. G. Nelson, and C. P. Pavlovich Molecular Profiling and Classification of Sporadic Renal Cell Carcinoma by Quantitative Methylation Analysis Clin. Cancer Res., November 1, 2004; 10(21): 7276 - 7283. [Abstract] [Full Text] [PDF]

				F. Sukosd, N. Kuroda, T. Beothe, A. P. Kaur, and G. Kovacs Deletion of Chromosome 3p14.2-p25 Involving the VHL and FHIT Genes in Conventional Renal Cell Carcinoma Cancer Res., January 15, 2003; 63(2): 455 - 457. [Abstract] [Full Text] [PDF]

				B. Gunawan, W. Huber, M. Holtrup, A. von Heydebreck, T. Efferth, A. Poustka, R.-H. Ringert, G. Jakse, and L. Fuzesi Prognostic Impacts of Cytogenetic Findings in Clear Cell Renal Cell Carcinoma: Gain of 5q31-qter Predicts a Distinct Clinical Phenotype with Favorable Prognosis Cancer Res., November 1, 2001; 61(21): 7731 - 7738. [Abstract] [Full Text] [PDF]

				C. Morrissey, A. Martinez, M. Zatyka, A. Agathanggelou, S. Honorio, D. Astuti, N. V. Morgan, H. Moch, F. M. Richards, T. Kishida, et al. Epigenetic Inactivation of the RASSF1A 3p21.3 Tumor Suppressor Gene in Both Clear Cell and Papillary Renal Cell Carcinoma Cancer Res., October 1, 2001; 61(19): 7277 - 7281. [Abstract] [Full Text] [PDF]

				W. M. Linehan, M. I. Lerman, and B. Zbar Identification of the von Hippel-Lindau (VHL) Gene: Its Role in Renal Cancer JAMA, February 15, 1995; 273(7): 564 - 570. [Abstract] [PDF]