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Chromosomal Changes in Mature Residual Teratomas following Polychemotherapy¹

Departments of Human Genetics [S. M. M. J. C., B. de J., V. J. S. I., R. S., G. J. te M.], Pathology [J. W. O., J. B.], Surgical Oncology [H. S. K.], and Medical Oncology [D. Th. S,], State University of Groningen, The Netherlands

A cytogenetic analysis of 13 mature residual teratomas following chemotherapy revealed modal chromosome numbers ranging from 52 to 85, in agreement with the flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. One tumor, however, lacked that marker.

The comparison between the chromosomal abnormalities found in mature residual teratomas following chemotherapy and those from primary testicular nonseminomas suggests that residual teratomas result from selection of clones from the primary tumor with a less abnormal karyotype.

¹ This work was supported by Grants GUKC 84-06 and GUKC 88-10 from the Netherlands Cancer Foundation (K. W. F.), by the Jan Kornelis de Cock Stichting, and by an institutional grant from the Hubrecht Laboratorium, Utrecht, The Netherlands.

² Member of the staff of the Department of Medical Genetics, Medical Faculty of Oporto, Portugal.

³ To whom requests for reprints should be addressed, at Department of Human Genetics, State University of Groningen, Antonius Deusinglaan 4, 9713 AW Groningen, The Netherlands.

Received 7/ 5/88. Revised 10/ 7/88. Accepted 10/18/88.

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