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Magnetic Resonance Spectroscopy of Tumors and Potential in Vivo Clinical Applications: A Review

Clinical Pharmacology [J. S. C.] and Pediatric Oncology [P. F. D.] Branches, National Cancer Institute, NIH, Bethesda, Maryland 20892

The development of nuclear magnetic resonance (NMR) spectroscopy as an established research tool for noninvasive studies of cancer cells and for in vivo studies of tumors in animals and humans has led to the possibility that this technique may be used in the future for clinical research studies and monitoring of therapy in cancer patients in combination with magnetic resonance imaging. This article provides a brief qualitative explanation of NMR spectroscopy and then reviews the cell and animal studies detailing which biochemicals can be observed in vivo by ³¹P, ¹³C, and ¹H NMR. The human studies done to date and their potential for diagnosis and monitoring of therapy are then discussed. In addition, ¹⁹F NMR spectroscopic studies of fluorinated drugs and ¹H and ³¹P NMR studies relating to drug resistance are mentioned. The current technical limitations and developing improvements are indicated also.

¹ Present address: Pittsburgh NMR Institute, 3260 Fifth Avenue, Pittsburgh, PA 15213.

² To whom requests for reprints should be addressed, at Clinical Pharmacology Branch, Building 10, Room 6N119, NIH, Bethesda, MD 20892.

Received 3/17/88. Revised 8/ 8/88. Revised 10/31/88. Accepted 11/10/88.

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