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Transcripts of the Insulin-like Growth Factors I and II in Human Hepatoma¹

Departments of Medical Research [T-S. S., S-H. H., C-K. C.] and General Surgery [W-Y. L., F-K. P.], Veterans General Hospital, and Graduate Institute of Microbiology and Immunology [T-S. S., S-H. H., C-K. C.], National Yang-Ming Medical College, Taipei, Taiwan, Republic of China; Department of Pediatrics, State University of Utrecht, Utrecht, The Netherlands [M. J.]; and Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510 [T. L. Y-F.]

Using complementary DNAs of human insulin-like growth factors as probes, expressions of the insulin-like growth factors I and II mRNA were examined in seven human hepatoma tissues and their adjacent nontumorous livers. The level of insulin-like growth factor I mRNA in hepatoma was lower than that in the nontumorous liver control. This phenomenon was probably caused by the low expression of human growth hormone receptor in hepatoma tissues. The levels of insulin-like growth factor II mRNA vary among hepatomas. Some show elevated expression; some have diminished expression compared to their nontumorous liver counterparts. In four of the seven hepatomas, expression of fetal forms of insulin-like growth factor II transcripts was observed and may represent dedifferentiation of insulin-like growth factor II expression during hepatocarcinogenesis.

¹ This work was supported by Research Grant NSC-75-0610-B075-73 from the National Science Council, Taiwan, Republic of China.

² To whom requests for reprints should be addressed, at Department of Medical Research, Veterans General Hospital, Taipei, Taiwan, Republic of China.

Received 11/30/87. Revised 9/ 6/88. Revised 12/ 5/88. Accepted 12/14/88.

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