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Abolishment of Metastasis Formation by Murine Tumor Cells Transfected with "Foreign" H-2K Genes¹

Department of Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel

High metastatic, low immunogenic Lewis lung carcinoma clones express low levels of H-2K^b major histocompatibility complex antigens. These cells metastasize spontaneously in mice with C57BL/6 genetic background possessing the H-2D^b locus. Transfection of different H-2K genes abrogates metastasis in H-2K, H-2D compatible mice and in C57BL/6 recipients. The transfected cells are potent inducers of H-2K-restricted and alloreactive cytotoxic lymphocytes that kill H-2K-positive cells and cross-react with parental nontransfected cells.

¹ The study was supported by USPHS Grant CA-28139 awarded by the National Cancer Institute, DHHS.

Received 10/18/88. Revised 1/31/89. Accepted 2/ 2/89.

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