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Cytogenetic Profile of in Vitro Spontaneously Transformed and Chemical Tumor-derived Cell Lines Related to the Mouse Lung Alveologenic Carcinoma¹

Carcinogenesis Research Unit, School of Pathology, University of New South Wales, P. O. Box 1, Kensington, New South Wales 2033, Australia

The karyotypes for a unique series of cloned untransformed and spontaneously and urethan-transformed mouse lung alveologenic carcinoma cell lines were compared by G-banding. All cell lines exhibited altered chromosome number accompanied by chromosomal aberrations. Both spontaneously and chemically transformed lines contained a higher proportion of cells carrying double minutes, short-arm chromosomes with no distinct banding pattern, and Robertsonian translocations between a variety of chromosomes. No common karyotypic abnormalities were observed among any of the transformed lines. These data suggest that enhanced genomic instability may lead to a critical subchromosomal molecular event(s) in generation of both spontaneously and chemically derived mouse lung alveologenic carcinoma.

¹ This work was supported by the New South Wales State Cancer Council and a grant from the National Health and Medical Research Council.

² To whom requests for reprints should be addressed.

Received 5/22/89. Revised 9/19/89. Accepted 9/27/89.