This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Okumoto, M. Articles by Hilgers, J. Search for Related Content PubMed PubMed Citation Articles by Okumoto, M. Articles by Hilgers, J.

Genetic Analysis of Resistance to Radiation Lymphomagenesis with Recombinant Inbred Strains of Mice¹

Department of Allied Biological Science, Research Institute, University of Osaka Prefecture, Shinkecho 174-16, Sakai 593, Japan [M. O., R. N.]; Department of Pathology, Nara Medical University, Kashiwara 634, Japan [S. I.]; and Department of Obstetrics and Gynecology, Academisch Ziekenhuis Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands [J. H.]

Induction of lymphomas by radiation in mice is controlled by genetic factors. We analyzed the genetic control of radiation lymphomagenesis using the CXS series of recombinant inbred strains derived from two progenitor strains: one highly susceptible to radiation induction of lymphoma [BALB/cHeA (C)] and one extremely resistant [STS/A (S)]. The best concordances between strain distribution patterns of genetic markers and resistance (or susceptibility) to radiation lymphomagenesis were observed in a region with the b and Ifa genes on chromosome 4. This indicates that one major locus controls the incidence of radiogenic lymphomas in mice. We designated this locus as the Lyr (lymphoma resistance) locus. Backcrosses of (CXS)F₁ to the two progenitor strains showed an intermediate incidence of lymphomas between their parental mice and did not significantly differ from (CXS)F₁ mice. This and previous observations that (CXS)F₁ mice also showed an intermediate incidence, differing from both progenitor strains, indicate that more genes are involved in the resistance (or susceptibility) to lymphoma induced by irradiation.

¹ This work was supported in part by a grant-in-aid from Japan Atomic Energy Research Institute, Japan.

² To whom requests for reprints should be addressed.

Received 11/29/89.

This article has been cited by other articles:

				Y. Kodama, Y. Yoshikai, Y. Tamura, S. Wakana, R. Takagi, O. Niwa, and R. Kominami The D5Mit7 locus on mouse chromosome 5 provides resistance to {gamma}-ray-induced but not N-methyl-N-nitrosourea-induced thymic lymphomas Carcinogenesis, January 1, 2004; 25(1): 143 - 148. [Abstract] [Full Text] [PDF]

				T. A. Dragani 10 Years of Mouse Cancer Modifier Loci: Human Relevance Cancer Res., June 15, 2003; 63(12): 3011 - 3018. [Abstract] [Full Text] [PDF]

				M. Gariboldi, R. Pascale, G. Manenti, M. R.D. Miglio, D. Calvisi, A. Carru, T. A. Dragani, and F. Feo Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain Carcinogenesis, July 1, 1999; 20(7): 1363 - 1368. [Abstract] [Full Text] [PDF]